T-bet and Gata3 in controlling type 1 and type 2 immunity mediated by innate lymphoid cells

Highlights ► A T-bet gradient controls fate and function of CCR6− ILC3s. ► T-bet and the control of ILC-mediated immunity to infections. ► Gata3 and ILC2 cell fate. ► ILC2P, a lineage specified progenitor of ILC2s.

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Bibliographic Details
Published in:	Current opinion in immunology Vol. 25; no. 2; pp. 139 - 147
Main Authors:	Hoyler, Thomas, Connor, Catherine A, Kiss, Elina A, Diefenbach, Andreas
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-04-2013
Subjects:	Allergy and Immunology Animals GATA3 Transcription Factor - metabolism Humans Immunity, Innate - genetics Immunity, Innate - immunology T-Box Domain Proteins - metabolism Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - immunology Th2 Cells - metabolism
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Summary:	Highlights ► A T-bet gradient controls fate and function of CCR6− ILC3s. ► T-bet and the control of ILC-mediated immunity to infections. ► Gata3 and ILC2 cell fate. ► ILC2P, a lineage specified progenitor of ILC2s.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2013.02.007