The radioprotective effect of a new aminothiol (20-PRA)
We examined the radioprotective effect of aminothiol 2-N-propylamine-cyclo-hexanethiol (20-PRA) on a human leukemic cell line (K562) following various radiation doses (5, 7.5 and 20 Gy) using a source of 60Co gamma-rays. At 5 Gy and 1 nM 20-PRA, a substantial protective effect (58%) was seen 24 h af...
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| Published in: | Brazilian journal of medical and biological research Vol. 31; no. 8; pp. 1095 - 1098 |
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| Abstract | We examined the radioprotective effect of aminothiol 2-N-propylamine-cyclo-hexanethiol (20-PRA) on a human leukemic cell line (K562) following various radiation doses (5, 7.5 and 20 Gy) using a source of 60Co gamma-rays. At 5 Gy and 1 nM 20-PRA, a substantial protective effect (58%) was seen 24 h after irradiation, followed by a decrease at 48 h (11%). At the high radiation dose (20 Gy) a low protective effect was also seen (35%). In addition, the antitumorigenic potential of 10 nM 20-PRA was shown by the inhibition of crown gall formation induced by Agrobacterium tumefaciens. The radioprotective potency of 20-PRA is 10(5)-10(6) times higher than that of the aminothiol WR-1065 (N-(2-mercaptoethyl)-1,3-diaminopropane) whose protective effect is in the 0.1 to 1.0 mM range. |
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| AbstractList | We examined the radioprotective effect of aminothiol 2-N-propylamine-cyclo-hexanethiol (20-PRA) on a human leukemic cell line (K562) following various radiation doses (5, 7.5 and 20 Gy) using a source of 60Co g -rays. At 5 Gy and 1 nM 20-PRA, a substantial protective effect (58%) was seen 24 h after irradiation, followed by a decrease at 48 h (11%). At the high radiation dose (20 Gy) a low protective effect was also seen (35%). In addition, the antitumorigenic potential of 10 nM 20-PRA was shown by the inhibition of crown gall formation induced by Agrobacterium tumefaciens. The radioprotective potency of 20-PRA is 105-106 times higher than that of the aminothiol WR-1065 (N-(2-mercaptoethyl)-1,3-diaminopropane) whose protective effect is in the 0.1 to 1.0 mM range. We examined the radioprotective effect of aminothiol 2-N-propylamine-cyclo-hexanethiol (20-PRA) on a human leukemic cell line (K562) following various radiation doses (5, 7.5 and 20 Gy) using a source of 60Co gamma-rays. At 5 Gy and 1 nM 20-PRA, a substantial protective effect (58%) was seen 24 h after irradiation, followed by a decrease at 48 h (11%). At the high radiation dose (20 Gy) a low protective effect was also seen (35%). In addition, the antitumorigenic potential of 10 nM 20-PRA was shown by the inhibition of crown gall formation induced by Agrobacterium tumefaciens. The radioprotective potency of 20-PRA is 10(5)-10(6) times higher than that of the aminothiol WR-1065 (N-(2-mercaptoethyl)-1,3-diaminopropane) whose protective effect is in the 0.1 to 1.0 mM range. |
| Author | Salas, C E Piló-Veloso, D Dolabela, M F Pereira, M T Lopes, M T Steffani, G M Nelson, D L |
| AuthorAffiliation | Universidade Federal de Minas Gerais |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9777017$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/carcin/6.6.929 10.2307/3576807 10.1002/1097-0142(19880115)61:2<252::AID-CNCR2820610209>3.0.CO;2-G 10.2307/3577188 10.2307/3577140 10.2307/3573667 10.2307/3579176 10.1055/s-2007-971236 |
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| Keywords | radioprotector antitumorigenic effect cytotoxic effect aminothiols |
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| References | Grdina DJ (ref7) 1991; 51 Ward JF (ref12) 1983 Smoluk GD (ref21) 1988; 48 Finney DJ (ref18) 1976 Galsky AG (ref20) 1980; 65 Oberley LW (ref22) 1979; 39 Scheive K (ref2) 1988; 61 Roots R (ref9) 1972; 21 Issels RD (ref14) 1989; 49 Grdina DJ (ref3) 1985; 6 Cesarone CF (ref6) 1988; 48 Yuhas JM (ref1) 1980; 3 Meyer BN (ref17) 1982; 45 Davidson DE (ref16) 1980 Green D (ref23) 1994; 54 Milas L (ref5) 1982; 42 Smoluk GD (ref19) 1986; 107 Grdina DJ (ref4) 1985; 45 Zheng S (ref10) 1988; 114 Rubin DB (ref13) 1996; 145 Purdie JW (ref8) 1983; 43 Chapman JD (ref11) 1973; 56 Murray D (ref15) 1988; 113 Grdina, DJ; Nagy, B; Hill, C; Wells, RL; Peraino, C 1985; 6 Issels, RD; Nagele, A 1989; 49 Green, D; Bensely, D; Schein, P 1994; 54 Smoluk, GD; Fahey, RC; Ward, JF 1986; 107 Yuhas, JM; Spellman, JM; Culo, F 1980; 3 Milas, L; Hunter, B; Reid, BO; Thames, HD 1982; 42 Purdie, JW; Inhaber, ER; Schnider, H; Labelle, JL 1983; 43 Roots, R; Okada, S 1972; 21 Grdina, DJ; Peraino, C; Carnes, BA; Hill, CK 1985; 45 Smoluk, GD; Fahey, RC; Calabro-Jones, PM; Aguilera, JA; Ward, JF 1988; 48 Galsky, AG; Wilsey, JP; Powell, RG 1980; 65 Chapman, JD; Reuvers, AP; Borsa, J; Greenstock, CL 1973; 56 Finney, DJ 1976 Grdina, DJ; Carnes, BA; Grahn, D; Sigdestad, CP 1991; 51 Murray, D; van, Ankeren SC; Milas, L; Meyn, R 1988; 113 Cesarone, CF; Scovassi, AI; Scarabelli, L; Izzo, R; Orunesu, M; Bertazzoni, U 1988; 48 Ward, JF; Nygaard, OF; Simic, MG 1983 Meyer, BN; Ferrigni, NR; Putnam, JE; Jacobsen, LB; Nichols, DE; McLaughlin, L 1982; 45 Oberley, LW; Buether, GR 1979; 39 Davidson, DE; Grenan, MM; Sweeney, TR; Brady, LW 1980 Scheive, K; Cox, D 1988; 61 Zheng, S; Newton, GL; Gonick, G; Fahey, RC; Ward, JF 1988; 114 Rubin, DB; Drab, EA; Kang, HJ; Baumann, FE; Blazek, ER 1996; 145 |
| References_xml | – volume: 51 start-page: 4125 issn: 0008-5472 year: 1991 ident: ref7 article-title: Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid publication-title: Cancer Research contributor: fullname: Grdina DJ – volume: 6 start-page: 929 issn: 0143-3334 year: 1985 ident: ref3 article-title: The radioprotector WR1065 reduces radiation induced mutations at the HGRPT locus in V79 cells publication-title: Carcinogenesis doi: 10.1093/carcin/6.6.929 contributor: fullname: Grdina DJ – year: 1976 ident: ref18 contributor: fullname: Finney DJ – volume: 49 start-page: 2082 issn: 0008-5472 year: 1989 ident: ref14 article-title: Promotion of cystine uptake, increase of glutathione biosynthesis and modulation of glutathione status by S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR-2721) in Chinese hamster cells publication-title: Cancer Research contributor: fullname: Issels RD – volume: 21 start-page: 329 issn: 0955-3002 year: 1972 ident: ref9 article-title: Protection of DNA molecules of cultured mammalian cells from radiation-induced single-strand scissions by various alcohols and SH compounds publication-title: International Journal of Radiation Biology contributor: fullname: Roots R – volume: 107 start-page: 194 issn: 0033-7587 year: 1986 ident: ref19 article-title: Equilibrium dialysis studies of the binding of the radioprotector compounds to DNA publication-title: Radiation Research doi: 10.2307/3576807 contributor: fullname: Smoluk GD – volume: 3 start-page: 211 year: 1980 ident: ref1 article-title: The role of WR-2721 in radiotherapy and/or chemotherapy publication-title: Cancer Clinical Trials contributor: fullname: Yuhas JM – volume: 61 start-page: 252 issn: 0008-543X year: 1988 ident: ref2 article-title: Mammary carcinoma developing after radiotherapy and chemotherapy from Hodgkin's disease publication-title: Cancer doi: 10.1002/1097-0142(19880115)61:2<252::AID-CNCR2820610209>3.0.CO;2-G contributor: fullname: Scheive K – volume: 42 start-page: 1888 issn: 0008-5472 year: 1982 ident: ref5 article-title: Protective effects of S-2-(3-aminopropylamino)-ethylphosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice publication-title: Cancer Research contributor: fullname: Milas L – start-page: 309 volume-title: Biological characteristics of some improved radioprotectors year: 1980 ident: ref16 contributor: fullname: Davidson DE – volume: 48 start-page: 3641 issn: 0008-5472 year: 1988 ident: ref21 article-title: Radioprotection of cells in culture by WR-2721 and derivatives: Form of drug responsible for protection publication-title: Cancer Research contributor: fullname: Smoluk GD – volume: 39 start-page: 1141 issn: 0008-5472 year: 1979 ident: ref22 article-title: Role of superoxide dismutase in cancer: a review publication-title: Cancer Research contributor: fullname: Oberley LW – volume: 113 start-page: 155 issn: 0033-7587 year: 1988 ident: ref15 article-title: Radioprotective action of WR-1065 on radiation-induced DNA strand breaks in cultured Chinese hamster ovary cells publication-title: Radiation Research doi: 10.2307/3577188 contributor: fullname: Murray D – volume: 114 start-page: 11 issn: 0033-7587 year: 1988 ident: ref10 article-title: Radioprotection of DNA by thiols: Relationship between the net charge on a thiol and its ability to protect DNA publication-title: Radiation Research doi: 10.2307/3577140 contributor: fullname: Zheng S – volume: 56 start-page: 291 issn: 0033-7587 year: 1973 ident: ref11 article-title: Chemical radioprotection and radiosensitization of mammalian cells growing in vitro publication-title: Radiation Research doi: 10.2307/3573667 contributor: fullname: Chapman JD – volume: 54 start-page: 738 issn: 0008-5472 year: 1994 ident: ref23 article-title: Preclinical evaluation of WR151327: an orally active chemotherapy protector publication-title: Cancer Research contributor: fullname: Green D – volume: 48 start-page: 3581 issn: 0008-5472 year: 1988 ident: ref6 article-title: Depletion of adenosine diphosphate-ribosyl transferase activity in rat liver during exposure to N-2-acetylaminofluorene: effect of thiols. publication-title: Cancer Research contributor: fullname: Cesarone CF – volume: 43 start-page: 517 issn: 0955-3002 year: 1983 ident: ref8 article-title: Interaction of cultured mammalian cells with WR 2721 and its thiol WR-1065: Implications for mechanism of radioprotection publication-title: International Journal of Radiation Biology contributor: fullname: Purdie JW – volume: 145 start-page: 210 issn: 0033-7587 year: 1996 ident: ref13 article-title: WR1065 and radioprotection of vascular endothelial cells: I. Cell proliferation, DNA synthesis and damage publication-title: Radiation Research doi: 10.2307/3579176 contributor: fullname: Rubin DB – volume: 65 start-page: 184 issn: 0032-0889 year: 1980 ident: ref20 article-title: Crown gall tumor disc biossay publication-title: Plant Physiology contributor: fullname: Galsky AG – start-page: 73 volume-title: Chemical aspects of DNA radioprotection year: 1983 ident: ref12 contributor: fullname: Ward JF – volume: 45 start-page: 5379 issn: 0008-5472 year: 1985 ident: ref4 article-title: Protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid against induction of altered hepatocyte foci in rats treated once with <FONT FACE="Symbol">g</FONT>-radiation within one day after birth publication-title: Cancer Research contributor: fullname: Grdina DJ – volume: 45 start-page: 31 year: 1982 ident: ref17 article-title: Brine shrimp: a convenient general bioassay for active plant constituents publication-title: Planta Medica doi: 10.1055/s-2007-971236 contributor: fullname: Meyer BN – volume: 61 start-page: 252 year: 1988 end-page: 254 article-title: Mammary carcinoma developing after radiotherapy and chemotherapy from Hodgkin's disease publication-title: Cancer contributor: fullname: Scheive, K; Cox, D – start-page: 73 year: 1983 end-page: 85 publication-title: Radioprotectors and Anticarcinogens contributor: fullname: Ward, JF; Nygaard, OF; Simic, MG – volume: 107 start-page: 194 year: 1986 end-page: 205 article-title: Equilibrium dialysis studies of the binding of the radioprotector compounds to DNA publication-title: Radiation Research contributor: fullname: Smoluk, GD; Fahey, RC; Ward, JF – volume: 114 start-page: 11 year: 1988 end-page: 27 article-title: Radioprotection of DNA by thiols: Relationship between the net charge on a thiol and its ability to protect DNA publication-title: Radiation Research contributor: fullname: Zheng, S; Newton, GL; Gonick, G; Fahey, RC; Ward, JF – volume: 45 start-page: 31 year: 1982 end-page: 34 article-title: Brine shrimp: a convenient general bioassay for active plant constituents publication-title: Planta Medica contributor: fullname: Meyer, BN; Ferrigni, NR; Putnam, JE; Jacobsen, LB; Nichols, DE; McLaughlin, L – volume: 21 start-page: 329 year: 1972 end-page: 342 article-title: Protection of DNA molecules of cultured mammalian cells from radiation-induced single-strand scissions by various alcohols and SH compounds publication-title: International Journal of Radiation Biology contributor: fullname: Roots, R; Okada, S – volume: 56 start-page: 291 year: 1973 end-page: 306 article-title: Chemical radioprotection and radiosensitization of mammalian cells growing in vitro publication-title: Radiation Research contributor: fullname: Chapman, JD; Reuvers, AP; Borsa, J; Greenstock, CL – volume: 6 start-page: 929 year: 1985 end-page: 931 article-title: The radioprotector WR1065 reduces radiation induced mutations at the HGRPT locus in V79 cells publication-title: Carcinogenesis contributor: fullname: Grdina, DJ; Nagy, B; Hill, C; Wells, RL; Peraino, C – start-page: 309 year: 1980 end-page: 320 publication-title: Radiation Sensitizers: Their Use in the Clinical Management of Cancer contributor: fullname: Davidson, DE; Grenan, MM; Sweeney, TR; Brady, LW – volume: 48 start-page: 3581 year: 1988 end-page: 3585 article-title: Depletion of adenosine diphosphate-ribosyl transferase activity in rat liver during exposure to N-2-acetylaminofluorene: effect of thiols. publication-title: Cancer Research contributor: fullname: Cesarone, CF; Scovassi, AI; Scarabelli, L; Izzo, R; Orunesu, M; Bertazzoni, U – volume: 65 start-page: 184 year: 1980 end-page: 185 article-title: Crown gall tumor disc biossay publication-title: Plant Physiology contributor: fullname: Galsky, AG; Wilsey, JP; Powell, RG – volume: 48 start-page: 3641 year: 1988 end-page: 3647 article-title: Radioprotection of cells in culture by WR-2721 and derivatives: Form of drug responsible for protection publication-title: Cancer Research contributor: fullname: Smoluk, GD; Fahey, RC; Calabro-Jones, PM; Aguilera, JA; Ward, JF – volume: 113 start-page: 155 year: 1988 end-page: 170 article-title: Radioprotective action of WR-1065 on radiation-induced DNA strand breaks in cultured Chinese hamster ovary cells publication-title: Radiation Research contributor: fullname: Murray, D; van, Ankeren SC; Milas, L; Meyn, R – volume: 145 start-page: 210 year: 1996 end-page: 216 article-title: WR1065 and radioprotection of vascular endothelial cells: I. Cell proliferation, DNA synthesis and damage publication-title: Radiation Research contributor: fullname: Rubin, DB; Drab, EA; Kang, HJ; Baumann, FE; Blazek, ER – volume: 49 start-page: 2082 year: 1989 end-page: 2086 article-title: Promotion of cystine uptake, increase of glutathione biosynthesis and modulation of glutathione status by S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR-2721) in Chinese hamster cells publication-title: Cancer Research contributor: fullname: Issels, RD; Nagele, A – volume: 43 start-page: 517 year: 1983 end-page: 527 article-title: Interaction of cultured mammalian cells with WR 2721 and its thiol WR-1065: Implications for mechanism of radioprotection publication-title: International Journal of Radiation Biology contributor: fullname: Purdie, JW; Inhaber, ER; Schnider, H; Labelle, JL – volume: 54 start-page: 738 year: 1994 end-page: 741 article-title: Preclinical evaluation of WR151327: an orally active chemotherapy protector publication-title: Cancer Research contributor: fullname: Green, D; Bensely, D; Schein, P – year: 1976 publication-title: Probits Analysis contributor: fullname: Finney, DJ – volume: 45 start-page: 5379 year: 1985 end-page: 5381 article-title: Protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid against induction of altered hepatocyte foci in rats treated once with <FONT FACE="Symbol">g</FONT>-radiation within one day after birth publication-title: Cancer Research contributor: fullname: Grdina, DJ; Peraino, C; Carnes, BA; Hill, CK – volume: 42 start-page: 1888 year: 1982 end-page: 1897 article-title: Protective effects of S-2-(3-aminopropylamino)-ethylphosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice publication-title: Cancer Research contributor: fullname: Milas, L; Hunter, B; Reid, BO; Thames, HD – volume: 3 start-page: 211 year: 1980 end-page: 216 article-title: The role of WR-2721 in radiotherapy and/or chemotherapy publication-title: Cancer Clinical Trials contributor: fullname: Yuhas, JM; Spellman, JM; Culo, F – volume: 39 start-page: 1141 year: 1979 end-page: 1149 article-title: Role of superoxide dismutase in cancer: a review publication-title: Cancer Research contributor: fullname: Oberley, LW; Buether, GR – volume: 51 start-page: 4125 year: 1991 end-page: 4130 article-title: Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid publication-title: Cancer Research contributor: fullname: Grdina, DJ; Carnes, BA; Grahn, D; Sigdestad, CP |
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| SubjectTerms | aminothiols Animals antitumorigenic effect BIOLOGY cytotoxic effect Humans MEDICINE, RESEARCH & EXPERIMENTAL Mercaptoethylamines - pharmacology Propylamines - pharmacology Radiation-Protective Agents - pharmacology radioprotector Sulfhydryl Compounds - pharmacology Tumor Cells, Cultured - drug effects |
| Title | The radioprotective effect of a new aminothiol (20-PRA) |
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