Relationship Between Chronic Inflammation and Cardiovascular Risk Factors in Children on Maintenance Hemodialysis

• Published in: Transplantation proceedings Vol. 37; no. 7; pp. 2915 - 2917
• Main Authors: Cengiz, N., Baskin, E., Agras, P.I., Sezgin, N., Saatci, U.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01-09-2005; Elsevier Science
• Subjects: Adolescent; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; Blood Proteins - analysis; C-Reactive Protein - analysis; Cardiology. Vascular system; Cardiovascular Diseases - epidemiology; Child; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Inflammation; Kidney Failure, Chronic - therapy; Male; Medical sciences; Prealbumin - analysis; Reference Values; Renal Dialysis - adverse effects; Risk Factors; Serum Albumin - analysis; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Human; Hemodialysis; Cardiovascular disease; Inflammation; Transplantation; Maintenance; Epidemiology; Vascular disease; Medicine; Extrarenal dialysis; Chronic; Treatment; Surgery; Atherosclerosis; Risk factor; Cardiovascular risk; Graft; Child
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2005.07.058

Cardiovascular disease is one of the most important causes of morbidity and mortality in
children with end-stage renal failure. Chronic inflammation and malnutrition have been
suggested to be risk factors for cardiovascular disease. However, to date, biomarkers of
inflammation have not been well studied in children. The aim of this study was to investigate
the relation between chronic inflammation and cardiovascular risk factors in children on
hemodialysis therapy. Twenty-seven patients on hemodialysis (14 girls, 13 boys) of mean
age 15.3 ± 2.4 years and 20 healthy children (13 girls, 7 boys) of mean age 14.3 ± 2.7 years
were included the study. C-reactive protein (CRP), albumin, prealbumin, transferrin, ferritin,
and fibrinogen were measured as the markers of inflammation. The levels of CRP, ferritin, and
erythrocyte sedimentation rate among hemodialysis patients were significantly higher than those of control subjects
(
P < .001 for all). Albumin and transferrin levels were found to be lower than those of control
group (
P = .02 and
P < .001, respectively). CRP levels were negatively correlated
with albumin, prealbumin, apoprotein A
1, HDL, and hemoglobin levels, and positively correlated
with erythropoietin/Htc ratios. This study suggests that hemodialyzed
children are exposed to chronic inflammation. In addition, CRP may be an indicator of chronic
inflammation related to cardiovascular risk factors, such as malnutrition, dyslipidemia, and
anemia. In conclusion, we suggest that the risk of cardiovascular disease could be reduced by
defining markers of chronic inflammation and malnutrition in hemodialyzed children and by
taking necessary measures at an early stage.