Declines in Lung Function After Antiretroviral Therapy Initiation in Adults With Human Immunodeficiency Virus and Tuberculosis: A Potential Manifestation of Respiratory Immune Reconstitution Inflammatory Syndrome

• Published in: Clinical infectious diseases Vol. 70; no. 8; pp. 1750 - 1753
• Main Authors: Auld, Sara C, Maenetje, Pholo, Ravimohan, Shruthi, Weissman, Drew, Ncube, Itai, Mlotshwa, Mandla, Ratsela, Nelly, Chase, William, Vangu, Mboyo-Di-Tamba, Wallis, Robert, Churchyard, Gavin, Kornfeld, Hardy, Bisson, Gregory P
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 10-04-2020
• Subjects: Adult; Brief Reports; HIV; HIV Infections - complications; HIV Infections - drug therapy; Humans; Immune Reconstitution Inflammatory Syndrome; Lung; Prospective Studies; Tuberculosis; pulmonary function; immune reconstitution inflammatory syndrome; HIV; tuberculosis
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1093/cid/ciz733

Abstract
End-organ impairment has received relatively little research attention as a possible manifestation of tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS). In this prospective cohort study, one-half of adults with human immunodeficiency virus and pulmonary tuberculosis experienced meaningful declines in lung function on antiretroviral therapy, suggesting a role for lung function in TB-IRIS definitions.