Global high-throughput screens for cellular function

There is a critical need for global methods that allow for high-throughput assessment of cellular function for clinical and basic scientists working in both academia and the pharmaceutical industry. These methods typically couple systematic inactivation strategies with high-throughput cell-based ass...

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Bibliographic Details
Published in:	Experimental Hematology Vol. 30; no. 5; pp. 381 - 387
Main Authors:	Hauptschein, Robert S, Eustace, Brenda K, Jay, Daniel G
Format:	Book Review Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-05-2002
Subjects:	Animals Cell Physiological Phenomena Genetic Testing Humans Mass Screening - methods
Online Access:	Get full text
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Summary:	There is a critical need for global methods that allow for high-throughput assessment of cellular function for clinical and basic scientists working in both academia and the pharmaceutical industry. These methods typically couple systematic inactivation strategies with high-throughput cell-based assays that facilitate rapid target validation. We present here a survey of these technologies and their applications. We discuss their promise and limitations in addressing the vast number of candidate molecules of disease relevance that are emerging from genomics and proteomics.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0301-472X 1873-2399
DOI:	10.1016/S0301-472X(02)00783-X