The FADS1 Genotype Modifies Metabolic Responses to the Linoleic Acid and Alpha‐linolenic Acid Containing Plant Oils–Genotype Based Randomized Trial FADSDIET2

• Published in: Molecular nutrition & food research Vol. 65; no. 7; pp. e2001004 - n/a
• Main Authors: Lankinen, Maria A., Mello, Vanessa D., Meuronen, Topi, Sallinen, Taisa, Ågren, Jyrki, Virtanen, Kirsi A., Laakso, Markku, Pihlajamäki, Jussi, Schwab, Ursula
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01-04-2021
• Subjects: Arachidonic acid; Diet; FADS1; Fatty acid composition; Fatty acids; Food intake; genotype; Genotype & phenotype; Genotypes; Homeostasis; Homozygotes; human; Inflammation; Insulin; Linoleic acid; Linolenic acid; Metabolic response; nutrition; Phospholipids; Polyunsaturated fatty acids; Statins; Sunflower oil; Sunflowers; nutrition; human; FADS1; polyunsaturated fatty acids; genotype
• ISSN: 1613-4125; 1613-4133
• DOI: 10.1002/mnfr.202001004

Scope
The article investigates the FADS1 rs174550 genotype interaction with dietary intakes of high linoleic acid (LA) and high alpha‐linolenic acid (ALA) on the response of fatty acid composition of plasma phospholipids (PLs), and of markers of low‐grade inflammation and glucose‐insulin homeostasis.
Methods and results
One‐hundred thirty homozygotes men for FADS1 rs174550 SNP (TT and CC genotypes) were randomized to an 8‐week intervention with either LA‐ or ALA‐enriched diet (13 E% PUFA). The source of LA and ALA are 30–50 mL of sunflower oil (SFO, 62–63% LA) and Camelina sativa oil (CSO, 30– are randomized to an 35% ALA), respectively. In the SFO arm, there is a significant genotype x diet interaction for the proportion of arachidonic acid in plasma phospholipids (p < 0.001), disposition index (DI30) (p = 0.039), and for serum high‐sensitive c‐reactive protein (hs‐CRP, p = 0.029) after excluding the participants with hs‐CRP concentration of >10 mg L‐1 and users of statins or anti‐inflammatory therapy. In the CSO arm, there are significant genotype x diet interactions for n‐3 polyunsaturated fatty acids, but not for the clinical characteristics.
Conclusions
The FADS1 genotype modifies the response to high PUFA diets, especially to high‐LA diet. These findings suggest that approaches considering FADS variation may be useful in personalized dietary counseling.
One‐hundred thirty men with different FADS1 genotypes are randomized to an 8‐wk dietary intervention with either high consumption of sunflower oil (source of n‐6 fatty acids) or Camelina sativa oil (source of n‐3 fatty acids). Participants with different genotypes showed a different response to dietary intake of sunflower oil in fatty acid metabolism and markers of low‐grade inflammation and glucose‐insulin homeostasis. Approaches considering FADS variation may be useful in personalized dietary counseling.