Testosterone free index correlates best with dehydroepiandrosterone sulfate

• Published in: Fertility and sterility Vol. 36; no. 6; p. 757
• Main Authors: Haning, Jr, R V, Carlson, I H, Shapiro, S S, Nolten, W E
• Format: Journal Article
• Language: English
• Published: United States 01-12-1981
• Subjects: Amenorrhea - blood; Dehydroepiandrosterone - blood; Female; Humans; Infertility, Female - blood; Luteal Phase; Menotropins - therapeutic use; Polycystic Ovary Syndrome - blood; Testosterone - blood
• ISSN: 0015-0282
• DOI: 10.1016/S0015-0282(16)45922-4

Correlation coefficients for dehydroepiandrosterone sulfate (DHEAS) were determined in women on menotropin. DHEAS was significantly correlated with testosterone free index (TFI), 0.78**; percentage free testosterone (%FT), 0.66**; androstenedione (delta 4A), 0.66*; luteinizing hormone (LH), 0.55**; LH/follicle-stimulating hormone (FSH) ratio, 0.55**; 17-OH-progesterone (17-P), 0.55**; testosterone (T), 0.53**; weight (WT), 0.40**, urinary estriol glucuronide (E3G), 0.33*; and free cortisol index (FFI), 0.32*, with 43 df but not with prolactin (PRL), 0.25. Normal male DHEAS (3.5 +/- 1.2, 25) (microgram/ml; mean +/- standard deviation, n) was higher than normal female DHEAS (2.4 +/- 1.1, 27), P less than 0.01 and DHEAS in women on oral contraceptives (1.9 +/- 1.1, 17) was slightly lower than in normal females, P greater than 0.2. In the combined population (male, female, and females on oral contraceptives) DHEAS was correlated with TFI (0.56**), T (0.54**), %FT (0.52**), delta 4A (0.40**), and age (-0.40**) with 66 df and 17-P (0.30*) with 54 df. TFI appears to be one determinant of plasma DHEAS, **P less than 0.01. *P less than 0.05.