The influence of decreased low-molecular-weight heparin nadroparin dose on diastolic blood pressure in patients on hemodialysis

• Published in: Clinical and applied thrombosis/hemostasis Vol. 18; no. 5; p. 519
• Main Authors: Sain, Milenka, Ljutic, Dragan, Kovacic, Vedran, Radic, Josipa, Jelicic, Ivo
• Format: Journal Article
• Language: English
• Published: United States 01-09-2012
• Subjects: Aged; Anticoagulants - administration & dosage; Blood Pressure - drug effects; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nadroparin - administration & dosage; Renal Dialysis; Time Factors
• ISSN: 1938-2723
• DOI: 10.1177/1076029611429123

The aim of present study was to assess the impact of decreasing single bolus dose of nadroparin on blood pressure in patients on hemodialysis (HD). Forty HD patients were included in this study. The bolus dose of nadroparin was decreased twice by 25%; this lower dose was maintained for last 4 weeks, during which the dose was adjusted. There were no significant differences between the first and the last predialysis: systolic blood pressure ([pre-SBP]; 131.05 ± 25.58 vs 125.92 ± 25.49 mm Hg; P = .133), diastolic blood pressure ([pre-DBP]; 73.82 ± 11.82 vs 72.89 ± 9.13 mm Hg; P = .653), and pulse pressure ([pre-PP]; 57.24 ± 20.39 vs 53.03 ± 21.20 mm Hg; P = .121). We found correlation between delta nadroparin and pre-DBP in the last HD (rho = 0.310; P = .031) but not between delta nadroparin and pre-SBP and pre-PP values. This is the first report of influence of nadroparin dose lowering on pre-DBP in HD patients.