Fibrous dysplasia of bone : case report with autopsy study 80 years after the original clinical recognition of the bone lesions

We present a report of the histological features of the bone lesions in a case of polyostotic fibrous dysplasia studied at autopsy in a patient aged 88 years. While much of the fibrous tissue of the lesions contained the trabeculae of non-lamellar bone that are a feature of fibrous dysplasia in youn...

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Published in:Skeletal radiology Vol. 26; no. 3; pp. 177 - 183
Main Authors: SISSONS, H. A, MALCOLM, A. J
Format: Journal Article
Language:English
Published: Berlin Springer 01-03-1997
Springer Nature B.V
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Abstract We present a report of the histological features of the bone lesions in a case of polyostotic fibrous dysplasia studied at autopsy in a patient aged 88 years. While much of the fibrous tissue of the lesions contained the trabeculae of non-lamellar bone that are a feature of fibrous dysplasia in young patients, other parts of the lesions showed evidence of osteoclastic remodelling of bone trabeculae, and even of the replacement of some of these structures by mature lamellar bone.
AbstractList We present a report of the histological features of the bone lesions in a case of polyostotic fibrous dysplasia studied at autopsy in a patient aged 88 years. While much of the fibrous tissue of the lesions contained the trabeculae of non-lamellar bone that are a feature of fibrous dysplasia in young patients, other parts of the lesions showed evidence of osteoclastic remodelling of bone trabeculae, and even of the replacement of some of these structures by mature lamellar bone.
We present a report of the histological features of the bone lesions in a case of polyostotic fibrous dysplasia studied at autopsy in a patient aged 88 years. While much of the fibrous tissue of the lesions contained the trabeculae of non-lamellar bone that are a feature of fibrous dysplasia in young patients, other parts of the lesions showed evidence of osteoclastic remodelling of bone trabeculae, and even of the replacement of some of these structures by mature lamellar bone.[PUBLICATION ABSTRACT]
Author SISSONS, H. A
MALCOLM, A. J
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  givenname: A. J
  surname: MALCOLM
  fullname: MALCOLM, A. J
  organization: Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom
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crossref_primary_10_1038_modpathol_2012_223
crossref_primary_10_1259_dmfr_56740531
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Cites_doi 10.1056/NEJM193704292161701
10.1002/jor.1100130111
10.2106/00004623-196244020-00001
10.1056/NEJM199112123252403
10.1111/j.1399-0004.1986.tb01261.x
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Keywords Endocrinopathy
Human
Case study
Autopsy
Pseudohypoparathyroidism
Diseases of the osteoarticular system
Albright disease
Female
Osteochondrodysplasia
Elderly
Genetic disease
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PublicationTitle Skeletal radiology
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References LS Weinstein (70260177256_CR8) 1991; 325
WH Harris (70260177256_CR2) 1962; 44
A Shenker (70260177256_CR9) 1994; 79
CK Ruth (70260177256_CR3) 1982; 5
SM Yabut (70260177256_CR6) 1988; 22
R Happle (70260177256_CR7) 1986; 29
DJ McCune (70260177256_CR5) 1936; 52
L Lichtenstein (70260177256_CR1) 1942; 3
F Albright (70260177256_CR4) 1937; 216
BA Alman (70260177256_CR10) 1995; 13
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  doi: 10.1056/NEJM193704292161701
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  ident: 70260177256_CR5
  publication-title: Am J Dis Child
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– volume: 13
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  doi: 10.2106/00004623-196244020-00001
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– volume: 79
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  ident: 70260177256_CR9
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  contributor:
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– volume: 325
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  publication-title: N Engl J Med
  doi: 10.1056/NEJM199112123252403
  contributor:
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Snippet We present a report of the histological features of the bone lesions in a case of polyostotic fibrous dysplasia studied at autopsy in a patient aged 88 years....
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StartPage 177
SubjectTerms Aged
Aged, 80 and over
Biological and medical sciences
Diseases of the osteoarticular system
Female
Fibrous Dysplasia, Polyostotic - diagnostic imaging
Fibrous Dysplasia, Polyostotic - pathology
Humans
Malformations and congenital and or hereditary diseases involving bones. Joint deformations
Medical sciences
Radiography
Title Fibrous dysplasia of bone : case report with autopsy study 80 years after the original clinical recognition of the bone lesions
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