Paracrine mechanisms of proliferative, anti-apoptotic and anti-inflammatory effects of mesenchymal stromal cells in models of acute organ injury

Abstract The purpose of this review is to systematize data from many studies and observations of proliferative, anti-apoptotic and anti-inflammatory effects of mesenchymal stromal cell (MSC) paracrine factors and their biologic effects in models of acute organ injury.

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Bibliographic Details
Published in:	Cytotherapy (Oxford, England) Vol. 16; no. 5; pp. 579 - 585
Main Authors:	Khubutiya, Mogeli S, Vagabov, Aleksandr V, Temnov, Andrey A, Sklifas, Alla N
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 01-05-2014
Subjects:	Advanced Basic Science Animals Apoptosis - physiology Cell Proliferation cytokines growth factors Humans Mesenchymal Stem Cell Transplantation mesenchymal stromal cell-derived conditioned medium mesenchymal stromal cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Other Paracrine Communication - physiology paracrine factors mesenchymal stromal cell-derived conditioned medium cytokines growth factors paracrine factors mesenchymal stromal cells
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Summary:	Abstract The purpose of this review is to systematize data from many studies and observations of proliferative, anti-apoptotic and anti-inflammatory effects of mesenchymal stromal cell (MSC) paracrine factors and their biologic effects in models of acute organ injury.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1465-3249 1477-2566
DOI:	10.1016/j.jcyt.2013.07.017