Study of the expression of cathepsins in histological material from pancreatic lesions

• Published in: Revista española de enfermedades digestivas Vol. 108; no. 12; pp. 780 - 784
• Main Authors: Martínez, Juan F, Aparicio, José Ramón, Peiró, Gloria, Cabezas, Antonio, Roger, Manuela, Ruiz, Francisco, Compañy, Luís, Casellas, Juan Antonio
• Format: Journal Article
• Language: English
• Published: Spain Sociedad Española de Patología Digestiva 01-12-2016; Aran Ediciones
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adenocarcinoma, Mucinous - metabolism; Adenocarcinoma, Mucinous - pathology; Adult; Aged; Case-Control Studies; Cathepsins; Cathepsins - biosynthesis; Female; Gastroenterology & Hepatology; Geriatrics & Gerontology; Humans; Infectious Diseases; Male; Middle Aged; Oncology; Pancreatic adenocarcinoma; Pancreatic Diseases - metabolism; Pancreatic Diseases - pathology; Pancreatic mucinous neoplasms; Pancreatic Neoplasms; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Pathology; Pharmacology & Pharmacy; Precancerous Conditions - metabolism; Precancerous Conditions - pathology; Radiology, Nuclear Medicine & Medical Imaging; Retrospective Studies; Surgery; Cathepsins; Pancreatic adenocarcinoma; Pancreatic mucinous neoplasms
• ISSN: 1130-0108
• DOI: 10.17235/reed.2016.3749/2015

To assess the expression levels of cathepsins in malignant and premalignant lesions.
We retrospectively included patients who underwent pancreatic surgery on pancreatic solid or cystic masses. The expression of cathepsin H, L, B and S was determined in both types of samples. Lesions were divided into three categories: malignant (pancreatic adenocarcinoma and malignant mucinous neoplasms), premalignant (mucinous neoplasms) and benign (other lesions).
Thirty-one surgical resection samples were studied. The expression of cathepsins was significantly higher in malignant lesions than in premalignant and benign lesions (H 75%, 27%, 37% p = 0.05; L 92%, 36%, 37% p = 0.011; B 83%, 36%, 62% p = 0.069; S 92%, 36%, 25% p = 0.004, respectively).
Cathepsins are overexpressed in histological samples of malignant lesions compared to premalignant and benign lesions. However, the expression of cathepsins is similar in both premalignant and benign lesions.