Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery

In a placebo-controlled trial involving patients undergoing cesarean delivery, prophylactic use of tranexamic acid did not lead to a significantly lower risk of a composite outcome of maternal death or blood transfusion.

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 388; no. 15; pp. 1365 - 1375
Main Authors:	Pacheco, Luis D., Clifton, Rebecca G., Saade, George R., Weiner, Steven J., Parry, Samuel, Thorp, John M., Longo, Monica, Salazar, Ashley, Dalton, Wendy, Tita, Alan T.N., Gyamfi-Bannerman, Cynthia, Chauhan, Suneet P., Metz, Torri D., Rood, Kara, Rouse, Dwight J., Bailit, Jennifer L., Grobman, William A., Simhan, Hyagriv N., Macones, George A.
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 13-04-2023
Subjects:	Acids Antifibrinolytic agents Antifibrinolytic Agents - adverse effects Antifibrinolytic Agents - therapeutic use Bleeding Blood Loss, Surgical - mortality Blood Loss, Surgical - prevention & control Blood products Blood Transfusion Blood transfusions Cesarean section Cesarean Section - adverse effects Chemoprevention Child Childbirth & labor Complications of Pregnancy Emergency medical care FDA approval Female Gynecology Gynecology General Hemoglobin Hemoglobins - analysis Hemorrhage Hormones Hospitals Humans Informed consent Maternal Death Maternal mortality Obstetrics Placebos Postpartum Postpartum Hemorrhage - blood Postpartum Hemorrhage - etiology Postpartum Hemorrhage - mortality Postpartum Hemorrhage - prevention & control Pregnancy Statistical analysis Thromboembolism Tranexamic Acid - adverse effects Tranexamic Acid - therapeutic use
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Description
Summary:	In a placebo-controlled trial involving patients undergoing cesarean delivery, prophylactic use of tranexamic acid did not lead to a significantly lower risk of a composite outcome of maternal death or blood transfusion.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 A list of all the members of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network is provided in the Supplementary Appendix, available at NEJM.org.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2207419