Cytogenetic and molecular characterization of a hepatosplenic T-cell lymphoma: report of a novel chromosomal aberration

Hepatosplenic T-cell lymphomas (HSTCL) are rare cancers and comprise 5% of peripheral T-cell lymphomas. These well-characterized extranodal lymphomas have a disguised onset, secondary to intrasinusoidal infiltration of the spleen, liver, and bone marrow, with a rapidly progressive course that is poo...

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Bibliographic Details
Published in:	Cancer genetics Vol. 204; no. 2; pp. 103 - 107
Main Authors:	Mandava, Swarna, Sonar, Reshma, Ahmad, Firoz, Yadav, Anil K, Chheda, Pratiksha, Ramani, Manisha, Gupta, Amar D, Das, Bibhu R
Format:	Journal Article
Language:	English
Published:	United States 01-02-2011
Subjects:	Chromosome Aberrations Genes, T-Cell Receptor beta Genes, T-Cell Receptor gamma Hematology, Oncology and Palliative Medicine Humans In Situ Hybridization, Fluorescence Liver Neoplasms - genetics Liver Neoplasms - pathology Lymphoma, T-Cell - genetics Lymphoma, T-Cell - pathology Male Medical Education Splenic Neoplasms - genetics Splenic Neoplasms - pathology Young Adult Hepatosplenic T-cell lymphomas novel cytogenetics TCR rearrangement immunophenotype
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Summary:	Hepatosplenic T-cell lymphomas (HSTCL) are rare cancers and comprise 5% of peripheral T-cell lymphomas. These well-characterized extranodal lymphomas have a disguised onset, secondary to intrasinusoidal infiltration of the spleen, liver, and bone marrow, with a rapidly progressive course that is poorly responsive to chemotherapy and often ensues in the setting of immune system suppression. We describe the clinical, immunophenotypic, cytogenetic, fluorescence in situ hybridization, and molecular analyses for T cell receptor gene rearrangement in a 21-year-old man diagnosed with HSTCL. Immunophenotypic analysis revealed negativity for CD5 as well as double negativity for CD4/CD8 mature T-cell immunophenotype, which suggested the diagnosis of hepatosplenic T-cell lymphoma. Molecular analysis confirmed a TCR gene rearrangement, thereby verifying the common T-cell origin of the present HSTCL case. Furthermore, cytogenetic analysis revealed a novel chromosomal rearrangement, t(7;15)(p22;q21). Metaphase fluorescence in situ hybridization analysis confirmed the translocation of a chromosomal segment from 15q21 to 7p22.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	2210-7762
DOI:	10.1016/j.cancergencyto.2010.08.021