Effects of diphenyl diselenide on lipid profile and hepatic oxidative stress parameters in ovariectomized female rats

• Published in: Journal of pharmacy and pharmacology Vol. 63; no. 5; pp. 663 - 669
• Main Authors: da Rocha, Juliana Trevisan, Pinton, Simone, Mazzanti, Alexandre, Mazzanti, Cinthia Melazzo, Beckemann, Diego Vilibaldo, Nogueira, Cristina Wayne, Zeni, Gilson
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-05-2011
• Subjects: Animals; Antioxidants - metabolism; Antioxidants - pharmacology; Ascorbic Acid - metabolism; Benzene Derivatives - pharmacology; cholesterol; Female; Hormones - deficiency; Intra-Abdominal Fat - metabolism; Lipids - blood; Liver - metabolism; menopause; Models, Animal; Obesity - prevention & control; Organoselenium Compounds - pharmacology; Ovariectomy; oxidative stress; Oxidative Stress - drug effects; Postmenopause - drug effects; Postmenopause - physiology; Rats; Rats, Wistar; selenium; Weight Gain - drug effects; Weight Gain - physiology
• ISSN: 0022-3573; 2042-7158
• DOI: 10.1111/j.2042-7158.2011.01255.x

Objectives  Ovarian hormone decline after menopause is linked to many pathophysiological reactions. Female rats submitted to ovariectomy are employed as a model of post‐menopausal condition. This study investigated the effects of diphenyl diselenide (PhSe)2 on body weight gain, intra‐abdominal fat deposition, plasma lipid profile and hepatic oxidative stress in ovariectomized rats.
Methods  Female adult Wistar rats were ovariectomized (OVX rats) or sham‐operated and divided into four groups: (i) sham‐operated, (ii) (PhSe)2, (iii) OVX and (iv) OVX + (PhSe)2. (PhSe)2 (5 mg/kg; 5 ml/kg, p.o.) was administered once a day for 30 days to groups (ii) and (iv). After that, rats were anaesthetized for blood sample gathering and submitted to euthanasia.
Key findings  (PhSe)2 (5 mg/kg) was effective in preventing the rise in body weight gain and intra‐abdominal fat deposition induced in OVX rats. Although (PhSe)2 was not effective in avoiding the increase in plasma total cholesterol and non‐HDL levels induced in OVX rats, (PhSe)2 reduced plasma triglycerides and augmented HDL levels in OVX rats. (PhSe)2 also increased hepatic ascorbic acid levels, reduced glutathione content, glutathione S‐transferase activity and restored catalase activity in liver of OVX rats.
Conclusions  These findings suggest that (PhSe)2 could be a promising alternative to minimize menopause related symptoms.