Chemotherapy of advanced gastric cancer with 72-hour continuous intravenous 5-fluorouracil infusion at 2-week intervals

Twenty-nine patients with advanced gastric adenocarcinoma were treated with 72-hour continuous intravenous infusion of 5-fluorouracil (30 mg/kg/24 hr) at 2-week intervals. Six patients (21%) achieved partial response and four (14%) had stabilization of their disease. The median duration of partial r...

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Bibliographic Details
Published in:	Medical and pediatric oncology Vol. 11; no. 5; p. 358
Main Authors:	Shah, A, MacDonald, W C
Format:	Journal Article
Language:	English
Published:	United States 1983
Subjects:	Adenocarcinoma - diagnosis Adenocarcinoma - drug therapy Adenocarcinoma - mortality Adult Aged Drug Administration Schedule Female Fluorouracil - administration & dosage Humans Infusions, Parenteral Male Middle Aged Stomach Neoplasms - diagnosis Stomach Neoplasms - drug therapy Stomach Neoplasms - mortality
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Summary:	Twenty-nine patients with advanced gastric adenocarcinoma were treated with 72-hour continuous intravenous infusion of 5-fluorouracil (30 mg/kg/24 hr) at 2-week intervals. Six patients (21%) achieved partial response and four (14%) had stabilization of their disease. The median duration of partial response was 8 months, with a range of 5-19 months. The median survival time for all patients from the start of chemotherapy was 8 months. Various prognostic factors important in determining response and survival are analyzed.
ISSN:	0098-1532
DOI:	10.1002/mpo.2950110513