Lepromatous leprosy treated with recombinant interferon gamma: cutaneous histologic changes

We report on the histologic changes occurring in single cutaneous lesions, from six active lepromatous patients, 1 week following the administration of three daily intradermal injections, 35 micrograms each, of recombinant interferon gamma (rIFN-gamma). Except for a strong induration at the injectio...

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Bibliographic Details
Published in:	International journal of dermatology Vol. 31; no. 11; p. 813
Main Authors:	Bottasso, O, Besuschio, S, Merlin, V, Morini, J C, Bernabo, J, Falcoff, R, Falcoff, E
Format:	Journal Article
Language:	English
Published:	England 01-11-1992
Subjects:	Adult Aged Biopsy Drug Administration Schedule Female Humans Injections, Intralesional Interferon-gamma - administration & dosage Interferon-gamma - therapeutic use Leprosy, Lepromatous - pathology Leprosy, Lepromatous - therapy Male Middle Aged Recombinant Proteins Skin - pathology Time Factors
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Summary:	We report on the histologic changes occurring in single cutaneous lesions, from six active lepromatous patients, 1 week following the administration of three daily intradermal injections, 35 micrograms each, of recombinant interferon gamma (rIFN-gamma). Except for a strong induration at the injection site, rIFN-gamma produced no adverse systemic reactions and was able to promote a remarkable influx of T-lymphocytes, mononuclear phagocytes with large nuclei, nonvacuolated cytoplasm, and reduced lysozyme reactivity. Furthermore, despite no clear-cut reduction of mycobacterial dermal burden, bacilli showed a clear increase in the granular appearance. Present findings provide a basis for further elucidation of rIFN-gamma as an additional tool for leprosy treatment.
ISSN:	0011-9059
DOI:	10.1111/j.1365-4362.1992.tb04253.x