Effects of prenalterol on renal function in normal man

• Published in: Acta anaesthesiologica Scandinavica Vol. 26; no. 6; p. 603
• Main Authors: Järnberg, P O, Westman, L
• Format: Journal Article
• Language: English
• Published: England 01-12-1982
• Subjects: Adrenergic beta-Agonists - pharmacology; Adult; Blood Pressure - drug effects; Catecholamines - blood; Heart Rate - drug effects; Humans; Kidney - drug effects; Kidney - physiology; Kidney Function Tests; Male; Practolol - analogs & derivatives; Practolol - pharmacology; Prenalterol; Renin - blood; Urodynamics
• ISSN: 0001-5172
• DOI: 10.1111/j.1399-6576.1982.tb01824.x

The effects of prenalterol infusion, 0.5 microgram/kg/min, on renal function were studied in 10 male volunteers. Systolic blood pressure increased by 22 mmHg (P less than 0.01) and diastolic pressure decreased by 11 mmHg (P less than 0.01). Heart rate increased by 11 beats/min (P less than 0.01). Plasma catecholamine levels and plasma renin activity were not altered. Renal haemodynamics were unchanged. Urine flow rate and fractional free water excretion decreased by 29% and 45%, respectively (P less than 0.01). Fractional sodium excretion increased by 19% (P less than 0.01) and fractional potassium excretion fell by 33% (P less than 0.05).