Idiopathic renal infarction

• Published in: The American journal of medicine Vol. 119; no. 4; p. 356.e9
• Main Authors: Bolderman, Rob, Oyen, Raymond, Verrijcken, Anton, Knockaert, Daniël, Vanderschueren, Steven
• Format: Journal Article
• Language: English
• Published: United States 01-04-2006
• Subjects: Acute Disease; Adult; Aged; Aged, 80 and over; C-Reactive Protein - metabolism; Diagnosis, Differential; Female; Hematuria - etiology; Humans; Infarction - diagnosis; Kidney - blood supply; Kidney - diagnostic imaging; Kidney Diseases - diagnosis; Kidney Diseases - diagnostic imaging; Kidney Diseases - enzymology; Kidney Diseases - pathology; L-Lactate Dehydrogenase - blood; Leukocyte Count; Male; Middle Aged; Prospective Studies; Radiography; Retrospective Studies; Risk Factors
• ISSN: 1555-7162
• DOI: 10.1016/j.amjmed.2005.06.049

Renal infarction may be an underrecognized disorder. Classical teaching holds that cardioemboli, notably in the setting of arterial fibrillation, are responsible. The expanding use of contrast enhanced computed tomography (CT) in patients with acute abdomen may change the spectrum of renal infarction.
Twenty-seven consecutive patients presenting to a single university hospital with nontraumatic CT-documented acute renal infarction were studied and stratified according to the presence or absence of cardiac disease, either obvious at presentation or detected during work-up.
Eleven patients (41%) had obvious cardiac disease, including atrial fibrillation in all but one. Sixteen patients (59%) had no discernible structural or arrhythmic cardiac disease and were classified as idiopathic group. Patients in the idiopathic group were significantly younger (median age in years [interquartile range]: 48 [41-53] versus 75 [53-82] years, P = .003) and, besides smoking, had fewer traditional cardiovascular risk factors.
Acute renal infarction may occur in individuals of middle age without risk factors for cardioembolism. In patients with renal colic without lithiasis the diagnosis of renal infarction should be considered especially if serum lactate dehydrogenase is elevated, even in the absence of atrial fibrillation.