RAIDS atlas of significant genetic and protein biomarkers in cervical cancer

RAIDS atlas of significant genetic and protein biomarkers in cervical cancer

Loss of function in epigenetic acting genes together with driver alterations in the PIK3CA pathway have been shown significantly associated with poor outcome in cervical squamous cell cancer. More recently, a CoxBoost analysis identified 16 gene alterations and 30 high level activated proteins to be...

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Bibliographic Details
Published in:Journal of gynecologic oncology Vol. 34; no. 5; p. e74
Main Authors: Scholl, Suzy, Roufai, Diana Bello, Chérif, Linda Larbi, Kamal, Maud
Format: Journal Article
Language:English
Published: Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology 01-09-2023
대한부인종양학회
Subjects:
Review
산부인과학
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Summary:Loss of function in epigenetic acting genes together with driver alterations in the PIK3CA pathway have been shown significantly associated with poor outcome in cervical squamous cell cancer. More recently, a CoxBoost analysis identified 16 gene alterations and 30 high level activated proteins to be of high interest, due to their association with either good or bad outcome, in the context of treatment received by chemoradiation. The objectives here were to review and confirm the significance of these molecular alterations as suggested by literature reports and to pinpoint alternate treatments options for poor-responders to chemoradiation.
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https://doi.org/10.3802/jgo.2023.34.e74
ISSN:2005-0380
2005-0399
DOI:10.3802/jgo.2023.34.e74