Pyrazolo[3,4-d]pyrimidine based scaffold derivatives targeting kinases as anticancer agents

Pyrazolopyrimidines are fused heterocyclic ring systems which structurally can consider as bioisosteres of adenine, which is fundamental for every aspect of cell life. Pyrazolo[3,4-d]pyrimidines derivatives have been explored for their inhibitory activity towards various protein kinase enzymes and t...

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Bibliographic Details
Published in:	Future Journal of Pharmaceutical Sciences Vol. 2; no. 1; pp. 20 - 30
Main Authors:	Nasser S.M. Ismail, Eslam M.H. Ali, Diaa A. Ibrahim, Rabah A.T. Serya, Dalal A. Abou El Ella
Format:	Journal Article
Language:	English
Published:	SpringerOpen 01-06-2016
Subjects:	Bioisostere Protein kinase Pyrazolo[3,4-d]pyrimidine SAR Synthetic strategy
Online Access:	Get full text
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Summary:	Pyrazolopyrimidines are fused heterocyclic ring systems which structurally can consider as bioisosteres of adenine, which is fundamental for every aspect of cell life. Pyrazolo[3,4-d]pyrimidines derivatives have been explored for their inhibitory activity towards various protein kinase enzymes and their role as anticancer agents. The present review to the best of our knowledge is the first compilation on synthesis and medicinal aspects including structure–activity relationships of pyrazolo[3,4-d]pyrimidines reported to date.
ISSN:	2314-7245
DOI:	10.1016/j.fjps.2016.02.002