Synthesis and evaluation of potent yaku'amide A analogs

• Published in: Chemical science (Cambridge) Vol. 13; no. 7; pp. 1899 - 1905
• Main Authors: Lo, Concordia C L, Joaquin, Daniel, Moyá, Diego A, Ramos, Alexander, Kastner, David W, White, Stephen M, Christensen, Blake L, Naglich, Joseph G, Degnen, William J, Castle, Steven L
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 16-02-2022; The Royal Society of Chemistry
• Subjects: Analogs; Anticancer properties; Cancer; Chemistry; Natural products; Synthesis
• ISSN: 2041-6520; 2041-6539
• DOI: 10.1039/d1sc05992k

Two full-length analogs of the anticancer peptide yaku'amide A (1a) and four partial structures have been synthesized. These analogs were identified by computational studies in which the three
- and
-ΔIle residues of the natural product were replaced by the more accessible dehydroamino acids ΔVal and ΔEnv. Of the eight possible analogs, modeling showed that the targeted structures 2a and 2b most closely resembled the three-dimensional structure of 1a. Synthesis of 2a and 2b followed a convergent route that was streamlined by the absence of ΔIle in the targets. Screening of the compounds against various cancer cell lines revealed that 2a and 2b mimic the potent anticancer activity of 1a, thereby validating the computational studies.