Levels of lipid peroxidation and antioxidant vitamins in plasma and erythrocytes of patients with ankylosing spondylitis

• Published in: Clinical biochemistry Vol. 44; no. 17; pp. 1412 - 1415
• Main Authors: NAZIROGLU, Mustafa, AKKUS, Selami, CELIK, Hakan
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01-12-2011; Elsevier
• Subjects: Adult; Ankylosing spondylitis; Antioxidant; Antioxidant redox system; Antioxidants - metabolism; Ascorbic Acid - blood; beta Carotene - blood; Biological and medical sciences; Biomarkers - blood; Blood Sedimentation; C-Reactive Protein - metabolism; Diseases of the osteoarticular system; Erythrocytes - enzymology; Erythrocytes - metabolism; Female; Glutathione - blood; Glutathione Peroxidase - blood; Humans; Inflammation; Inflammatory joint diseases; Investigative techniques, diagnostic techniques (general aspects); Lipid Peroxidation; Male; Malondialdehyde - blood; Medical sciences; Oxidative stress; Spondylitis, Ankylosing - blood; Vitamin A - blood; Vitamin E - blood; Young Adult; CRP; Antioxidant redox system; Oxidative stress; GSH-Px; LP; BADSAI; ESR; SOD; Inflammation; MDA; Antioxidant; PMN; AS; BASFI; ROS; Hb; PUFAs; GSH; Ankylosing spondylitis; BMI; Human; Diseases of the osteoarticular system; Vitamin; Red blood cell; Lipids; Inflammatory joint disease; Spine disease; Blood plasma; Spondylarthropathy; Chronic; Clinical biology; Quantitative analysis; Peroxidation
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2011.09.005

The aim of this study was to investigate plasma and erythrocytes antioxidant vitamins and lipid peroxidation (LP) levels in patients with ankylosing spondylitis (AS) and controls.
The study was performed on the blood of 13 AS patients and 13 controls. Plasma and erythrocyte samples were obtained from blood of the patients and controls.
Erythrocyte sedimentation ratio, C-reactive protein level, Bath AS disease activity index and bath AS functional index were higher in patients with AS than in controls. Vitamins A, C, E and β-carotene concentrations in plasma, reduced glutathione (GSH) and glutathione peroxidase values in erythrocyte were lower in patients with AS than in controls. LP concentrations were higher in the plasma and erythrocyte of the patients than in controls.
These results provide some evidence for a potential role of increased lipid peroxidation and decreased antioxidant vitamins in ankylosing spondylitis.
► Lipid peroxidation concentrations in plasma and erythrocytes of patients with AS were increased. ► Plasma vitamins A, C, E, β-carotene and erythrocyte GSH and GSH-Px values were lower in patients with AS than in controls. ► We observed the presence of oxidative stress in the patients. ► The current study is the first to compare the role of antioxidant redox systems in the plasma of patients with AS.