Magnetic-Luminescent Theranostics of Cancer Based on Ytterbium Complexes of Porphyrins and Magnetite Nanoparticles

• Published in: Journal of communications technology & electronics Vol. 67; no. 7; pp. 884 - 889
• Main Authors: Shilov, I. P., Rumyantseva, V. D., Ivanov, A. V., Gorshkova, A. S.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-07-2022; Springer; Springer Nature B.V
• Subjects: Applications of Radiotechnology and Electronics in Biology and Medicine; Cancer; Communications Engineering; Engineering; Hyperthermia; Laboratory animals; Lexan (trademark); Magnetite; Nanocomposites; Nanoparticles; Networks; Organs; Polycarbonates; Polymers; Porphyrins; Selectivity; Tumors; Ytterbium
• ISSN: 1064-2269; 1555-6557
• DOI: 10.1134/S1064226922070129

In this paper we develop the fundamentals of a promising method of magnetoluminescent theranostics of tumors with visually and endoscopically accessible localization. The method is based on the use of composite nanoparticles consisting of a Lexan-type polymer matrix (nanocomposite shell) with incorporated ytterbium complexes of porphyrins (a hydrophobic ytterbium complex of hematoporphyrin IX tetramethyl ether), as well as magnetite nanoparticles. In this case, nanoparticles of the ytterbium porphyrin complex incorporated into the polymer matrix are responsible for carrying out the process of luminescent tumor diagnostics while magnetite nanoparticles provide tumor therapy through magnetic hyperthermia. The optimal size range of magnetic nanoparticles used in this method is shown to be
d
= 10–20 nm. Studies on the biodistribution of the nanocomposite in various organs and tumors of laboratory animals (female mice of the Bulb/c line with transplanted Ehrlich carcinoma) showed a significant selectivity of the accumulation of nanoparticles in the tumor as early as 24 h after intravenous administration.