Comparison of testosterone, FSH, LH and E2 hormone levels in infertility suspected males with COVID-19 infection

• Published in: Medicine (Baltimore) Vol. 102; no. 43; p. e35256
• Main Authors: Gökalp Özkorkmaz, Ebru, Özdemir Başaran, Süreyya, Afşin, Muhamet, Aşir, Firat
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 27-10-2023
• Subjects: Adult; Clinical Trial/Experimental Study; COVID-19; Estradiol; Female; Follicle Stimulating Hormone; Humans; Infertility, Male; Luteinizing Hormone; Male; Middle Aged; Testosterone; Young Adult
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000035256

Coronavirus disease 2019 (COVID-19) is an infectious disease that has many adverse impacts on many systems including reproduction. The direct effects of COVID-19 on urogenital system are still open to argue. This study aimed to compare testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) hormone levels in COVID-19 infected male individuals with infertility suspicion.
One hundred five control (healthy) and 105 COVID-19 infected males aged between 20 to 54 years old were enrolled in the study. All patients were either diagnosed with primary or secondary infertility suspicion. The COVID-19 infection was diagnosed via reverse-transcription polymerase chain reaction test. Blood samples from patients were analyzed from the control and COVID-19 group to measure serum testosterone, FSH, LH, and E2 levels. Hormone levels were statistically compared between groups with the Independent T test.
In control and COVID-19 patients, no significance was determined for FSH and LH hormone values. Testosterone hormone were significantly decreased and E2 level was statistically increased in COVID-19 patients compared to that in the control group (P < .001).
COVID-19 is a viral disease that affects organ including gonads. COVID-19 infection decreased testosterone levels and increased E2 levels, which leading to disorders in male and female reproductivity.