Potential protective function of green tea polyphenol EGCG against high glucose-induced cardiac injury and aging

• Published in: Journal of functional foods Vol. 104; p. 105506
• Main Authors: Wan, Chunpeng (Craig), Hu, Xiaomeng, Li, Mingxi, Rengasamy, Kannan R.R., Cai, Yi, Liu, Zhonghua
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-05-2023; Elsevier
• Subjects: Aging; Dietary supplements; EGCG; Green tea; Inflammation; Aging; Inflammation; Green tea; EGCG; Dietary supplements
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2023.105506

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•Nine active ingredients in green tea corresponded to 124 targets were crossed.•EGCG inhibited HG-induced cardiomyocyte hypertrophy.•PPARG-dependent pathways were involved in the protective effects.
Green tea and its active extracts have been widely used in a variety of dietary supplements. However, to date, the interaction of these bioactive compounds in green tea and their protein targets are not well studied. We first used the bioinformatics analysis of the relevant diabetes-related targets with the green tea bioactive compounds target proteins to construct a protein interaction (PPI) network to screen the core targets. The results of in vitro experiments showed that EGCG, a major polyphenolic component of green tea, inhibited HG-induced cardiomyocyte hypertrophy, inflammation, oxidative stress response, and cellular senescence. It was found that the PPARG-dependent pathways were involved in the protective effects of EGCG against HG-induced myocardial injury and senescence. This study comprehensively explored the role of EGCG in high glucose-induced myocardial cell injury and aging.