Increasing association between a neuropeptide Y promoter polymorphism and body mass index during the course of development
Summary What is already known about this subject? NPY serves as a potent orexigenic signal and plays an important role in body weight regulation. Recently, evidence for the impact of NPY gene variation on body weight regulation and risk of obesity was provided. Research has indicated that genetic in...
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| Published in: | Pediatric obesity Vol. 7; no. 6; pp. 453 - 460 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Blackwell Publishing Ltd
01-12-2012
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Summary
What is already known about this subject?
NPY serves as a potent orexigenic signal and plays an important role in body weight regulation. Recently, evidence for the impact of NPY gene variation on body weight regulation and risk of obesity was provided.
Research has indicated that genetic influences on some traits such as BMI change with age, with often showing a stronger effect as children mature.
What this study adds?
We show first evidence from a longitudinal study, demonstrating an association between NPY rs16147 genotype and BMI development from infancy into young adulthood.
The NPY effect appears to increase with age, being more pronounced in older age groups than in younger ones.
Objective
To investigate the association of the neuropeptide Y (NPY) promoter polymorphism rs16147 with body mass index (BMI) during the course of development from infancy to adulthood.
Design
Longitudinal, prospective study of a German community sample.
Subjects
n = 306 young adults (139 males, 167 females).
Measurements
Participants’ body weight and height were assessed at the ages of 3 months and 2, 4.5, 8, 11, 15 and 19 years. NPY rs16147 was genotyped.
Results
Controlling for a number of possible confounders, homozygote carriers of the rs16147 C allele exhibited significantly lower BMI scores when compared with individuals carrying the T allele. In addition, a significant genotype by age interaction emerged, indicating that the genotype effect increased during the course of development.
Conclusions
This is the first longitudinal study to report an association between rs16147 and BMI during childhood and adolescence. The finding that this effect increased during the course of development may either be due to age‐dependent alterations in gene expression or to maturation processes within the weight regulation circuits of the central nervous system. |
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| Bibliography: | German Research Foundation (DFG) ark:/67375/WNG-S847JQRK-F Federal Ministry for Education and Research Table S1. Number of missing body mass index (BMI) data at each assessment.Section S1. The number of participants providing information about weight and height by telephone interview at age 19 years was n = 27 (8.8 %). A re-analysis at age 19 years was carried out with the reduced sample of which data about weight and height had been assessed objectively. Significant group differences supported the demonstrated effect of neuropeptide Y (NPY) rs16147 on BMI [C homozygotes vs. T allele carriers F {1, 276} = 5.01; P = 0.026].Section S2. In total, 22 data points in 21 subjects were unavailable. Table S1 depicts the number of replaced data points at the different assessments. A repeated-measures analysis of covariance (ANCOVA) was carried out, including only those subjects with a complete data history to determine the effects of genotype and genotype by age interaction on variation in BMI. The significant main effect of NPY genotype [F {1, 282} = 4.73; P < 0.031], age [F {6, 1692} = 65.54; P < 0.001] and the interaction thereof [F {6, 1692} = 3.04; P < 0.042] was confirmed in the reduced sample of n = 285 participants.Section S3. Additional analyses were conducted to explore the genotype effect on weight at different ages. In parallel to the results for BMI, post hoc comparisons showed that genotype effects on weight were significant in older age groups (15 years [F {1, 303} = 5.75; P = 0.017] and 19 years [F {1, 303} = 4.92; P = 0.027]). In addition, a significant group difference emerged at the age of 8 years [F {1, 303} = 4.22; P = 0.041], while there was no such effect in the younger age groups (3 months [F {1, 303} = 1.62; P = 0.205], 2 years [F {1, 303} = 3.56; P = 0.060], 4.5 years [F {1, 303} = 1.20; P = 0.274]), (see Fig. ). However, differences according to NPY genotype failed to reach statistical significance at age 11 years [F {1, 303 = 1.70; P = 0.193]. ArticleID:IJPO69 istex:D21BA938AD32195E01A5D6746AF28F89217C603F ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 2047-6302 2047-6310 |
| DOI: | 10.1111/j.2047-6310.2012.00069.x |