Maradolipids: Diacyltrehalose Glycolipids Specific to Dauer Larva in Caenorhabditis elegans

Don't stress: Maradolipids (see picture; red O, grey C, white H) are the first diacyltrehaloses found to be produced in animal organisms. The nematode Caenorhabditis elegans synthesizes maradolipids for the highly stress‐resistant dauer larvae. Genetic knockout studies result in the improper mo...

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Published in:	Angewandte Chemie (International ed.) Vol. 49; no. 49; pp. 9430 - 9435
Main Authors:	Penkov, Sider, Mende, Fanny, Zagoriy, Vyacheslav, Erkut, Cihan, Martin, René, Pässler, Ulrike, Schuhmann, Kai, Schwudke, Dominik, Gruner, Margit, Mäntler, Jana, Reichert-Müller, Thomas, Shevchenko, Andrej, Knölker, Hans-Joachim, Kurzchalia, Teymuras V
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley-VCH Verlag 03-12-2010 WILEY-VCH Verlag WILEY‐VCH Verlag
Subjects:	Animals biosynthesis Caenorhabditis elegans - chemistry Caenorhabditis elegans - growth & development Caenorhabditis elegans - metabolism diacyltrehaloses glycolipids Glycolipids - chemistry Glycolipids - isolation & purification Glycolipids - metabolism Larva - chemistry Larva - growth & development Larva - metabolism natural products Temperature
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Summary:	Don't stress: Maradolipids (see picture; red O, grey C, white H) are the first diacyltrehaloses found to be produced in animal organisms. The nematode Caenorhabditis elegans synthesizes maradolipids for the highly stress‐resistant dauer larvae. Genetic knockout studies result in the improper morphology of the gut lumen of dauer larvae. Maradolipids might be important for understanding the chemical basis for the resistance of dauer larvae to extreme environmental stress.
Bibliography:	http://dx.doi.org/10.1002/anie.201004466 Human Frontier Scientific Program DFG ESF EuroMembrane Network - No. KN 240/13-1 ESF EuroMembrane Network - No. KU 945/2-1 ark:/67375/WNG-LHNSCJ5T-X istex:F523AA8F6EBDDB58CA4B36F64506D6AA098B24D0 ArticleID:ANIE201004466 We thank all members of the Kurzchalia lab for helpful discussions. We want to acknowledge CGC for providing worm strains. We are indebted to Dr. Suzanne Eaton (MPI-CBG, Dresden) and Dr. Eugeni Entchev (King's College, London) for critical reading of the manuscript. Work in the Kurzchalia laboratory was supported by the ESF EuroMembrane Network (DFG grant KU 945/2-1) and Human Frontier Scientific Program. Work in the Knölker laboratory was supported by the ESF EuroMembrane Network (DFG grant KN 240/13-1). Work in the Shevchenko laboratory was supported by the TRR 83 grant (Project A17) from the DFG. We thank all members of the Kurzchalia lab for helpful discussions. We want to acknowledge CGC for providing worm strains. We are indebted to Dr. Suzanne Eaton (MPI‐CBG, Dresden) and Dr. Eugeni Entchev (King’s College, London) for critical reading of the manuscript. Work in the Kurzchalia laboratory was supported by the ESF EuroMembrane Network (DFG grant KU 945/2‐1) and Human Frontier Scientific Program. Work in the Knölker laboratory was supported by the ESF EuroMembrane Network (DFG grant KN 240/13‐1). Work in the Shevchenko laboratory was supported by the TRR 83 grant (Project A17) from the DFG. These authors contributed equally to this work ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201004466