Effects of storage on the pyruvate-lactate system and random migration of human granulocytes

This work demonstrates a time-dependent loss of polymorphonuclear neutrophilic leukocyte (PMN) functions during the first 48 h with only slight lysis and release of cellular LDH. It confirms that storage decreases ATP levels in PMNs and significantly increases intracellular lactate and pyruvate. The...

Full description

Saved in:

Bibliographic Details
Published in:	Vox sanguinis Vol. 52; no. 1-2; p. 24
Main Authors:	Paul, J L, el Abbouyi, A, Roch-Arveiller, M, Giroud, J P, Agneray, J, Yonger, J, Raichvarg, D
Format:	Journal Article
Language:	English
Published:	England 01-03-1987
Subjects:	Adenosine Triphosphate - blood Blood Preservation Cell Movement Humans In Vitro Techniques L-Lactate Dehydrogenase - metabolism Lactates - blood Lactic Acid Neutrophils - physiology Pyruvates - blood Pyruvic Acid
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This work demonstrates a time-dependent loss of polymorphonuclear neutrophilic leukocyte (PMN) functions during the first 48 h with only slight lysis and release of cellular LDH. It confirms that storage decreases ATP levels in PMNs and significantly increases intracellular lactate and pyruvate. These data correlated with an inhibition of PMN migratory function and a considerable decrease in chemiluminescence response.
ISSN:	0042-9007
DOI:	10.1111/j.1423-0410.1987.tb02983.x