Synthesis of camptothecin–amino acid carbamate linkers

A more convenient and facile approach for the synthesis and production of camptothecin–amino acids carbamate linkers, that can be used in the synthesis of bioconjugate peptides JF-10-81, JF-10-71, and other peptide analogs designed to target somatostatin receptors has been described.

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Bibliographic Details
Published in:	Amino acids Vol. 42; no. 5; pp. 1727 - 1733
Main Authors:	Etienne, Marcus A., Kostochka, Mikhail, Fuselier, Joseph A., Coy, David H.
Format:	Journal Article
Language:	English
Published:	Vienna Springer Vienna 01-05-2012 Springer Nature B.V
Subjects:	Amino acids Amino Acids - chemistry Analogs Analytical Chemistry Biochemical Engineering Biochemistry Biomedical and Life Sciences Camptothecin - chemistry Carbamates - chemistry Life Sciences Neurobiology Original Article Peptides Peptides - chemical synthesis Prodrugs - chemical synthesis Proteomics Receptors Solid-Phase Synthesis Techniques Synthesis Camptothecin Amino acids Linkers Somatostatin Bioconjugates
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Summary:	A more convenient and facile approach for the synthesis and production of camptothecin–amino acids carbamate linkers, that can be used in the synthesis of bioconjugate peptides JF-10-81, JF-10-71, and other peptide analogs designed to target somatostatin receptors has been described.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0939-4451 1438-2199
DOI:	10.1007/s00726-011-0884-4