Xanthine oxidase inhibitory activity of Lychnophora species from Brazil (“Arnica”)

Twenty-two extracts from five Lychnophora species and one Lychnophoriopsis species, traditionally used in Brazil as analgesic, anti-inflammatory, and to treat bruise and rheumatism were examined for the inhibition of xanthine oxidase (XO), the enzyme that catalyses the metabolism of hypoxanthine and...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 107; no. 1; pp. 79 - 82
Main Authors:	Ferraz Filha, Z.S., Vitolo, I.F., Fietto, L.G., Lombardi, J.A., Saúde-Guimarães, D.A.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 11-08-2006 Elsevier
Subjects:	Asteraceae Asteraceae - chemistry Bioassay Biological and medical sciences Brazilian native plants chemical constituents of plants enzyme inhibitors Enzyme Inhibitors - pharmacology ethnobotany General pharmacology herbal medicines Lychnophora Lychnophora ericoides Lychnophora staavioides Lychnophora trichocarpha Lychnophoriopsis candelabrum Medical sciences medicinal plants medicinal properties Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - pharmacology Species Specificity traditional medicine Xanthine oxidase Xanthine Oxidase - antagonists & inhibitors Brazil South America America Xanthine oxidase Bioassay Brazilian native plants Lychnophora Asteraceae Enzyme Pharmacognosy Compositae Medicinal plant Dicotyledones Angiospermae Plant origin Spermatophyta Oxidoreductases Species
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Twenty-two extracts from five Lychnophora species and one Lychnophoriopsis species, traditionally used in Brazil as analgesic, anti-inflammatory, and to treat bruise and rheumatism were examined for the inhibition of xanthine oxidase (XO), the enzyme that catalyses the metabolism of hypoxanthine and xanthine into uric acid. Sixteen extracts were tested. All of them were found to have excellent XO inhibitory activity, with inhibitions greater than 38% at 100 μg/mL in the assay mixture. The most active plants examined were Lychnophora trichocarpha, Lychnophora ericoides, Lychnophora staavioides and Lychnophoriopsis candelabrum, with inhibitions of 77%, 78%, 66% and 63% at 100 μg/mL, respectively, and IC 50 values of 6.16, 8.28, 33.97 and 37.70 μg/mL, respectively.
Bibliography:	http://dx.doi.org/10.1016/j.jep.2006.02.011 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0378-8741 1872-7573
DOI:	10.1016/j.jep.2006.02.011