Acute rejection of a cryopreserved arterial homograft

• Published in: Cell and tissue banking Vol. 16; no. 3; pp. 331 - 333
• Main Authors: Soquet, Jérôme, Chambon, Jean-Pierre, Goffin, Yves, Jashari, Ramadan
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-09-2015; Springer Nature B.V
• Subjects: Acute Disease; Adult; Biomedical and Life Sciences; Biomedicine; Brief Communication; Cell Biology; Cryopreservation; Cryotherapy; Femoral Artery - transplantation; Graft Rejection - diagnosis; Graft Rejection - etiology; Histology; Humans; Life Sciences; Male; Middle Aged; Reoperation; Skin & tissue grafts; Thrombosis - complications; Thrombosis - surgery; Transplant Surgery; Treatment Failure; Treatment Outcome; Veins & arteries; Rejection; Cryopreservation; Arterial homograft
• ISSN: 1389-9333; 1573-6814
• DOI: 10.1007/s10561-014-9489-y

The use of arterial homograft is indicated especially in case of prosthetic graft infections after bypass surgery. We report the case of a patient who experienced the loss of a cryopreserved femoral artery caused by an acute rejection. This homograft had to be explanted 1 month after implantation because of an acute aneurysmal deterioration. Histology of the explanted artery showed inflammatory cells infiltration, pseudoaneurysms and necrosis. It was then replaced by a second cryopreserved femoral artery which is currently well tolerated. This first case of acute rejection of a cryopreserved artery, to our knowledge, raises again the question of the immunogenicity of cryopreserved homografts. The case report is followed by a brief discussion.