Overexpression of Human Lipoprotein Lipase Increases Hormone-Sensitive Lipase Activity in Adipose Tissue of Mice

An elevation of lipoprotein lipase (LPL) activity in adipose tissue is considered a possible cause of obesity. However, transgenic mice that overexpress the human LPL gene showed no increase in fat deposition as compared with controls. In the present study, we investigated effects of LPL on fat accu...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 211; no. 3; pp. 761 - 766
Main Authors:	Shimada, M., Ishibashi, S., Yamamoto, K., Kawamura, M., Watanabe, Y., Gotoda, T., Harada, K., Inaba, T., Ohsuga, J., Yazaki, Y., Yamada, N.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 26-06-1995
Subjects:	Adipose Tissue - metabolism Adipose Tissue, Brown - metabolism Animals Blotting, Northern Body Composition Body Weight Humans Lipoprotein Lipase - biosynthesis Lipoprotein Lipase - genetics Mice Mice, Transgenic Muscle, Skeletal - metabolism Oxygen Consumption Recombinant Proteins - biosynthesis RNA, Messenger - analysis Sterol Esterase - biosynthesis Sterol Esterase - genetics Triolein - metabolism
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