AKT capture by feline leukemia virus

Oncogene-containing retroviruses are generated by recombination events between viral and cellular sequences, a phenomenon called “oncogene capture”. The captured cellular genes, referred to as “v- onc ” genes, then acquire new oncogenic properties. We report a novel feline leukemia virus (FeLV), des...

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Bibliographic Details
Published in:	Archives of virology Vol. 162; no. 4; pp. 1031 - 1036
Main Authors:	Kawamura, Maki, Umehara, Daigo, Odahara, Yuka, Miyake, Ariko, Ngo, Minh Ha, Ohsato, Yoshiharu, Hisasue, Masaharu, Nakaya, Masa-aki, Watanabe, Shinya, Nishigaki, Kazuo
Format:	Journal Article
Language:	English
Published:	Vienna Springer Vienna 01-04-2017 Springer Nature B.V
Subjects:	Amino acids Animals Biomedical and Life Sciences Biomedicine Brief Report Cat Diseases - enzymology Cat Diseases - genetics Cat Diseases - virology Cats Cloning Genes Genomes Immunology Infectious Diseases Kinases Leukemia Leukemia Virus, Feline - genetics Leukemia Virus, Feline - metabolism Localization Lymphoma Medical Microbiology Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Recombination, Genetic Retroviridae Retroviridae Infections - enzymology Retroviridae Infections - genetics Retroviridae Infections - veterinary Retroviridae Infections - virology Tumor Virus Infections - enzymology Tumor Virus Infections - genetics Tumor Virus Infections - veterinary Tumor Virus Infections - virology Veterinary medicine Virology Japan FeLV FeLV v Transduction c FeLV v-AKT c-AKT1 FeLV-AKT
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Summary:	Oncogene-containing retroviruses are generated by recombination events between viral and cellular sequences, a phenomenon called “oncogene capture”. The captured cellular genes, referred to as “v- onc ” genes, then acquire new oncogenic properties. We report a novel feline leukemia virus (FeLV), designated “FeLV– AKT ”, that has captured feline c- AKT1 in feline lymphoma. FeLV– AKT contains a gag–AKT fusion gene that encodes the myristoylated Gag matrix protein and the kinase domain of feline c-AKT1, but not its pleckstrin homology domain. Therefore, it differs structurally from the v- Akt gene of murine retrovirus AKT8. AKT may be involved in the mechanisms underlying malignant diseases in cats.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s00705-016-3192-1