Colonoscopy and chromoscopy in hereditary colorectal cancer syndromes

• Published in: Familial cancer Vol. 15; no. 3; pp. 453 - 455
• Main Authors: Jenkins Wessling, Erin, Lanspa, Stephen J.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-07-2016; Springer Nature B.V
• Subjects: Adenoma - diagnosis; Adenoma - genetics; Biomedical and Life Sciences; Biomedicine; Cancer Research; Capsule Endoscopes; Capsule Endoscopy; Colonoscopes; Colonoscopy - methods; Colonoscopy - trends; Colorectal cancer; Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis; Colorectal Neoplasms, Hereditary Nonpolyposis - genetics; Colorectal Neoplasms, Hereditary Nonpolyposis - prevention & control; Coloring Agents - administration & dosage; Early Detection of Cancer - methods; Early Detection of Cancer - trends; Epidemiology; Human Genetics; Humans; Original Article; Precision Medicine - methods; Adenomas; Chromoscopy; Indigo carmine; Lynch syndrome
• ISSN: 1389-9600; 1573-7292
• DOI: 10.1007/s10689-016-9881-9

With hereditary colorectal cancer prevention studies it is difficult to demonstrate reduced mortality. Large populations are needed with well characterized genetics followed over a long period of time. Those studies do exist for standard white light colonoscopy surveillance in Lynch syndrome, but not for newer technologies including chromoscopy. For these newer technologies adenoma detection rate becomes the stand-in for mortality, and the assumption is made that surveillance efficacy impacts cancer occurrence. Though well-designed and important work exists in this area, the data do not support firm conclusions regarding the use of chromoscopy in Lynch syndrome.