Effect of Solanum lycocarpum St. Hill on various haematological parameters in diabetic rats

• Published in: Journal of ethnopharmacology Vol. 106; no. 3; pp. 442 - 444
• Main Authors: Perez, A.C., Franca, V., Daldegan, V.M., Duarte, I.D.G.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 19-07-2006; Elsevier
• Subjects: Alloxan; Animals; antioxidants; Antioxidants - administration & dosage; Antioxidants - pharmacology; Antioxidants - therapeutic use; Biological and medical sciences; Blood Glucose - drug effects; chemical constituents of plants; diabetes; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - prevention & control; ethnobotany; General pharmacology; herbal medicines; Hypoglycaemic agent; hypoglycemic agents; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Male; Medical sciences; medicinal plants; medicinal properties; Nitrates - blood; Nitric oxide; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; plant extracts; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Rats; Rats, Wistar; Solanum; Solanum lycocarpum; traditional medicine; Brazil; Solanum lycocarpum; Hypoglycaemic agent; Nitric oxide; Endocrinopathy; Rat; Pharmacognosy; Diabetes mellitus; Rodentia; Medicinal plant; Vertebrata; Hypoglycemic agent; Mammalia; Dicotyledones; Animal; Angiospermae; Plant origin; Spermatophyta; Solanaceae; Solanum
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2006.02.017

Solanum lycocarpum St. Hill (SL) is commonly used in Brazilian folk medicine. The aim of the present study was to evaluate the validity of the traditional therapeutic indication of SL as hypoglycaemic agent. The extract reduced glycemia to 92.4
mg/dl in alloxan induced diabetic rats (230.5
mg/dl). We also investigated the potential of SL as antioxidant (it reduced in 27% nitrate generation in diabetic animals). Our results also demonstrated that SL is not ulcerogenic and restored haemoglobin and haematocrit to normal values in diabetic animals.