Pathogenesis of liver lesions in mice following a primary infection with Ascaris suum

The development of liver lesions in mice infected with Ascaris suum is described and compared to the lesions in pigs. The findings suggest that liver necroses in mice are initially periacinar (centrilobular), caused by anoxia resulting from a vascular obstruction by the A. suum larvae located in the...

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Bibliographic Details
Published in:	Veterinary pathology Vol. 18; no. 6; p. 804
Main Author:	Bindseil, E
Format:	Journal Article
Language:	English
Published:	United States 01-11-1981
Subjects:	Animals Ascariasis - etiology Ascariasis - pathology Ascariasis - veterinary Hypoxia - complications Liver - pathology Liver Diseases, Parasitic - pathology Liver Diseases, Parasitic - veterinary Mice Mice, Inbred Strains Necrosis Species Specificity Swine Time Factors
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Summary:	The development of liver lesions in mice infected with Ascaris suum is described and compared to the lesions in pigs. The findings suggest that liver necroses in mice are initially periacinar (centrilobular), caused by anoxia resulting from a vascular obstruction by the A. suum larvae located in the sinusoids; and that the lesions in pigs following a primary infection have a different pathogenesis. It is concluded that mice are unsuitable models for studying the pathogenesis of A. suum-induced liver lesions in pigs.
ISSN:	0300-9858
DOI:	10.1177/030098588101800610