Facile Methods for the Synthesis of 5-Aryl and 5-Iodo Pyrrolo[2,3-d]pyrimidines

Facile Methods for the Synthesis of 5-Aryl and 5-Iodo Pyrrolo[2,3-d]pyrimidines

An efficient and environmentally benign one‐pot method has been developed for the synthesis of 4‐amino‐5‐arylpyrrolo[2,3‐d]pyrimidines. Phthalimido acetophenones were reacted with cyanoacetamide to give 2‐amino‐4‐phenyl‐1H‐pyrrole‐3‐carboxamides, which were further converted to 5‐aryl‐3H‐pyrrolo[2,3...

Full description

Saved in:
Bibliographic Details
Published in:Journal of heterocyclic chemistry Vol. 51; no. S1; pp. E380 - E383
Main Authors: Venkata Rao, K., Raghu Prasad, M., Raghuram Rao, A.
Format: Journal Article
Language:English
Published: Hoboken Blackwell Publishing Ltd 01-08-2014
Wiley Subscription Services, Inc
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient and environmentally benign one‐pot method has been developed for the synthesis of 4‐amino‐5‐arylpyrrolo[2,3‐d]pyrimidines. Phthalimido acetophenones were reacted with cyanoacetamide to give 2‐amino‐4‐phenyl‐1H‐pyrrole‐3‐carboxamides, which were further converted to 5‐aryl‐3H‐pyrrolo[2,3‐d]pyrimidin‐4‐ones. A novel method is also developed for the synthesis of 4‐amino‐5‐iodopyrrolo[2,3‐d]pyrimidines.
Bibliography:istex:F312B7EB08B07462EDDD3C574F1656C2BD05E125
ark:/67375/WNG-7NSQ6WQS-W
ArticleID:JHET1937
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.1937