Combinatorial Synthesis of Peptide Arrays with a Laser Printer

Special delivery: The “freezing” of activated amino acid derivatives within solid particles enables a laser printer to deliver these “postal packages” to defined locations on a solid support with high resolution. Subsequent parallel coupling is initiated simply by melting a whole layer of 20 differe...

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Published in:	Angewandte Chemie (International ed.) Vol. 47; no. 37; pp. 7132 - 7135
Main Authors:	Stadler, Volker, Felgenhauer, Thomas, Beyer, Mario, Fernandez, Simon, Leibe, Klaus, Güttler, Stefan, Gröning, Martin, König, Kai, Torralba, Gloria, Hausmann, Michael, Lindenstruth, Volker, Nesterov, Alexander, Block, Ines, Pipkorn, Rüdiger, Poustka, Annemarie, Bischoff, F. Ralf, Breitling, Frank
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley-VCH Verlag 01-09-2008 WILEY-VCH Verlag WILEY‐VCH Verlag
Subjects:	amino acids Amino Acids - chemistry biotechnology combinatorial chemistry high-throughput screening Lasers Peptide Library peptides Peptides - chemical synthesis Printing - instrumentation Protein Array Analysis - methods
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Summary:	Special delivery: The “freezing” of activated amino acid derivatives within solid particles enables a laser printer to deliver these “postal packages” to defined locations on a solid support with high resolution. Subsequent parallel coupling is initiated simply by melting a whole layer of 20 different amino acid particles (see schematic representation; Fmoc=9‐fluorenylmethoxycarbonyl).
Bibliography:	http://dx.doi.org/10.1002/anie.200801616 HFSPO - No. RGP5/2006 European Union - No. 508399 istex:A0273CE12C9C37EBFAD74A671699241B2AF2A7EE Helmholtz Society - No. VH-VI-108 We thank Dorothea Freidank, Daniela Rambow, Thorsten Kühlwein, and Jürgen Kretschmer for technical assistance, Martina Schnölzer (DKFZ) for mass spectrometry, Hans Lehrach for helpful discussions and encouragement, Kazuhiro Ohmori (Sekisui) for advice in particle composition, Alexander Küller, Michael Grunze, and Reiner Dahint (University of Heidelberg) for surface-analytical methods, and the BMBF (grant nos. 03N8710 and NGFN-0313375), the Helmholtz Society (grant no. VH-VI-108), the HFSPO (grant no. RGP5/2006), the European Union (grant no. 508399), and the Volkswagenstiftung (grant no. 79 466) for financial support. BMBF - No. 03N8710; No. NGFN-0313375 ArticleID:ANIE200801616 Volkswagenstiftung - No. 79 466 ark:/67375/WNG-K98K44PC-B These authors contributed equally to this work. Deceased on May 3 2008 We thank Dorothea Freidank, Daniela Rambow, Thorsten Kühlwein, and Jürgen Kretschmer for technical assistance, Martina Schnölzer (DKFZ) for mass spectrometry, Hans Lehrach for helpful discussions and encouragement, Kazuhiro Ohmori (Sekisui) for advice in particle composition, Alexander Küller, Michael Grunze, and Reiner Dahint (University of Heidelberg) for surface‐analytical methods, and the BMBF (grant nos. 03N8710 and NGFN‐0313375), the Helmholtz Society (grant no. VH‐VI‐108), the HFSPO (grant no. RGP5/2006), the European Union (grant no. 508399), and the Volkswagenstiftung (grant no. 79 466) for financial support. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200801616