Mouse Models of Gastrointestinal Tumorigenesis for Dietary Cancer Prevention Studies

• Published in: Nutrition reviews Vol. 61; no. 7; pp. 255 - 258
• Main Authors: Lamprecht, Sergio A, Lipkin, Martin
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-07-2003; International Life Sciences Institute; Oxford University Press
• Subjects: Adenomatous Polyposis Coli - genetics; Animals; Biological and medical sciences; cancer; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens; colon; Colonic Neoplasms - genetics; Colonic Neoplasms - prevention & control; Colorectal cancer; Diet; Digestive system; Folic Acid - therapeutic use; Foods and miscellaneous; knockout mice; Medical sciences; Mice; Models, Biological; Nutrition; Preventive medicine; small intestine; Tumors; Animal model; Digestive system; Rodentia; Transgenic animal; Malignant tumor; Anticarcinogen; Carcinogenesis; Small intestine; Feeding; Prevention; Vertebrata; Mammalia; Diet; Mouse; Colon
• ISSN: 0029-6643; 1753-4887
• DOI: 10.1301/nr.2003.jul.255-258

Mouse models have been generated to help identify dietary components that are protective against gastrointestinal tumorigenesis. Some of the models are produced by gene‐targeting procedures, whereas others use the normal mouse as an experimental animal. These preclinical mouse models have provided valuable information on the chemopreventive efficacy of specific nutrients greatly enhancing our understanding of the molecular mechanisms involved in gastrointestinal tumorigenesis.