Chromosomal Assignments of the Genes Coding for Human Types II, III, and IV Collagen: A Dispersed Gene Family

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 82; no. 10; pp. 3330 - 3334
• Main Authors: Solomon, E., Hiorns, L. R., Spurr, N., Kurkinen, M., Barlow, D., Hogan, B. L. M., Dalgleish, R.
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 01-05-1985; National Acad Sciences
• Subjects: Amino acids; Animals; Biological and medical sciences; Chromosome Mapping; Chromosomes; Chromosomes, Human, 1-3; Chromosomes, Human, 13-15; Chromosomes, Human, 6-12 and X; Classical genetics, quantitative genetics, hybrids; Collagen - genetics; Collagens; DNA; DNA probes; DNA Restriction Enzymes; Fundamental and applied biological sciences. Psychology; Genes; Genetics of eukaryotes. Biological and molecular evolution; Human; Human genetics; Humans; Hybrid cells; Hybrid Cells - physiology; Hybridity; Mice; Somatic cells; Genetic mapping; Human; Gene; C12-Chromosome; Collagen; Biological evolution; A2-Chromosome; D13-Chromosome; Multigene family; Localization
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.82.10.3330

The human type II collagen gene, COL2A1, has been assigned to chromosome 12, the type III gene, COL3A1, to chromosome 2, and one of the type IV genes, COL4A1, to chromosome 13. These assignments were made by using cloned genes as probes on Southern blots of DNA from a panel of mouse/human somatic cell hybrids. The two genes of type I collagen, COL1A1 and COL2A1, have been mapped previously to chromosomes 17 and 7, respectively. This family of conserved genes seems therefore to be dispersed throughout the genome.