A study of plasma disposition kinetics of lacidipine after single oral ascending doses

This study was designed to assess the plasma disposition kinetics of single oral 4-, 6-, and 8-mg doses of lacidipine, a new once-daily calcium-entry blocker. Seventeen healthy volunteers attended the study. In almost all cases, detectable levels were found up to 24 h after the drug administration,...

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Bibliographic Details
Published in:	Journal of cardiovascular pharmacology Vol. 23 Suppl 5; p. S94
Main Authors:	Squassante, L, Caveggion, E, Braggio, S, Pellegatti, M, Baroldi, P
Format:	Journal Article
Language:	English
Published:	United States 1994
Subjects:	Administration, Oral Adult Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - pharmacokinetics Calcium Channel Blockers - pharmacology Chromatography, High Pressure Liquid Dihydropyridines - administration & dosage Dihydropyridines - pharmacokinetics Dihydropyridines - pharmacology Female Half-Life Hemodynamics - drug effects Humans Male Radioimmunoassay
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Summary:	This study was designed to assess the plasma disposition kinetics of single oral 4-, 6-, and 8-mg doses of lacidipine, a new once-daily calcium-entry blocker. Seventeen healthy volunteers attended the study. In almost all cases, detectable levels were found up to 24 h after the drug administration, using a new HPLC-RIA assay. The usual pharmacokinetic parameters were calculated: Cmax, tmax, AUCinf, lambda z and t1/2. The half-life was similar after all doses, around 7 h, whereas Cmax and AUCinf did not show a linear correlation with the doses.
ISSN:	0160-2446
DOI:	10.1097/00005344-199423005-00020