Comparative study of sucralfate 2 grams twice daily versus sucralfate 1 gram four times daily in the treatment of benign gastric ulcers in outpatients

• Published in: The American journal of medicine Vol. 91; no. 2A; p. 68S
• Main Authors: Simjee, A E, Pettengell, K E, Spitaels, J M
• Format: Journal Article
• Language: English
• Published: United States 08-08-1991
• Subjects: Adult; Aged; Ambulatory Care; Double-Blind Method; Endoscopy, Gastrointestinal; Female; Humans; Male; Middle Aged; Patient Compliance; Prospective Studies; Stomach Ulcer - diagnosis; Stomach Ulcer - drug therapy; Stomach Ulcer - psychology; Sucralfate - administration & dosage; Sucralfate - pharmacology; Sucralfate - therapeutic use; Wound Healing - drug effects
• ISSN: 0002-9343
• DOI: 10.1016/0002-9343(91)90454-6

In a double-blind, randomized study, we compared the healing of gastric ulcer during a twice-daily regimen of 2 g sucralfate or sucralfate 1 g q.i.d. Patients receiving the former therapy received the tablets one-half hour before breakfast and at bedtime. Patients receiving sucralfate 1 g q.i.d. received their therapy 30 minutes before breakfast, lunch, and supper, and at bedtime. The study included 52 patients with endoscopically proven gastric ulcer; 41 patients completed the study. Healing was endoscopically assessed at 8 weeks and 12 weeks. After 8 and 12 weeks the healing rate for sucralfate 2 g b.i.d. was 67% and 92%, respectively; the healing rate of sucralfate 1 g q.i.d. was 59% and 71%, respectively. No statistically significant difference was found between the two regimens. The results suggest that 2 g sucralfate twice daily is as effective in the healing of gastric ulcer as 1 g sucralfate q.i.d.