Topographic Mapping of the Primary Sensory Cortex Using Intraoperative Optical Imaging and Tactile Irritation

• Published in: Brain topography Vol. 36; no. 1; pp. 1 - 9
• Main Authors: Polanski, Witold H., Oelschlägel, Martin, Juratli, Tareq A., Wahl, Hannes, Krukowski, Pawel M., Morgenstern, Ute, Koch, Edmund, Steiner, Gerald, Schackert, Gabriele, Sobottka, Stephan B.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-01-2023; Springer Nature B.V
• Subjects: Anesthesia; Biomedical and Life Sciences; Biomedicine; Brain; Brain mapping; Brain Mapping - methods; Brain Neoplasms - surgery; Brain tumors; Cerebral blood flow; Cerebral Cortex; Cortex (somatosensory); Functional magnetic resonance imaging; Glioma - surgery; Humans; Irritation; Magnetic Resonance Imaging - methods; Mapping; Median nerve; Neuroimaging; Neurology; Neurosciences; Neurosurgery; Psychiatry; Short Communication; Topography; Functional MRI; Sensory irritation; Intraoperative optical imaging
• ISSN: 0896-0267; 1573-6792
• DOI: 10.1007/s10548-022-00925-w

The determination of exact tumor boundaries within eloquent brain regions is essential to maximize the extent of resection. Recent studies showed that intraoperative optical imaging (IOI) combined with median nerve stimulation is a helpful tool for visualization of the primary sensory cortex (PSC). In this technical note, we describe a novel approach of using IOI with painless tactile irritation to demonstrate the feasibility of topographic mapping of different body regions within the PSC. In addition, we compared the IOI results with preoperative functional MRI (fMRI) findings. In five patients with tumors located near the PSC who received tumor removal, IOI with tactile irritation of different body parts and fMRI was applied. We showed that tactile irritation of the hand in local and general anesthesia leads to reliable changes of cerebral blood volume during IOI. Hereby, we observed comparable IOI activation maps regarding the median nerve stimulation, fMRI and tactile irritation of the hand. The tactile irritation of different body areas revealed a plausible topographic distribution along the PSC. With this approach, IOI is also suitable for awake surgeries, since the tactile irritation is painless compared with median nerve stimulation and is congruent to fMRI findings. Further studies are ongoing to standardize this method to enable a broad application within the neurosurgical community.