Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: Focus on the role of hypocretin and melatonin

Highlights ► AD pathology leads to sleep disturbances and circadian disruptions. ► Sleep disturbances have a negative influence on the quality of life of patients and care givers. ► Sleep deprivation and hypocretin increase Aβ levels and plaque deposition. ► Melatonin has anti-amyloidgenic propertie...

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Bibliographic Details
Published in:	Ageing research reviews Vol. 12; no. 1; pp. 188 - 200
Main Authors:	Slats, Diane, Claassen, Jurgen A.H.R, Verbeek, Marcel M, Overeem, Sebastiaan
Format:	Journal Article
Language:	English
Published:	England 01-01-2013
Subjects:	Alzheimer Disease - complications Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer Disease - psychology Circadian Rhythm - physiology Humans Internal Medicine Intracellular Signaling Peptides and Proteins - metabolism Intracellular Signaling Peptides and Proteins - physiology Melatonin - metabolism Melatonin - physiology Neurology Neuropeptides - metabolism Neuropeptides - physiology Orexins Sleep - physiology Sleep Wake Disorders - etiology Sleep Wake Disorders - physiopathology Sleep disorders Melatonin Circadian rhythm Hypocretin Dementia
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Summary:	Highlights ► AD pathology leads to sleep disturbances and circadian disruptions. ► Sleep disturbances have a negative influence on the quality of life of patients and care givers. ► Sleep deprivation and hypocretin increase Aβ levels and plaque deposition. ► Melatonin has anti-amyloidgenic properties. ► Important role of both melatonin and hypocretin in modulating AD pathophysiology.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1568-1637 1872-9649
DOI:	10.1016/j.arr.2012.04.003