Epigenetic ConFUSION: SS18-SSX Fusion Rewires BAF Complex to Activate Bivalent Genes in Synovial Sarcoma

In this issue of Cancer Cell, McBride and colleagues report that the synovial sarcoma SS18-SSX fusion drives BAF complex recruitment to bivalent domains repressed by PRC2 complex to orchestrate aberrant transcriptional activation. Redistribution of BAF localization is a major driver of synovial sarc...

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Bibliographic Details
Published in:	Cancer cell Vol. 33; no. 6; pp. 951 - 953
Main Authors:	Morgan, Marc A., Shilatifard, Ali
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 11-06-2018
Subjects:	Adult Cell Nucleus Child Epigenomics Humans Oncogene Proteins, Fusion - genetics Sarcoma, Synovial Transcriptional Activation
Online Access:	Get full text
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Summary:	In this issue of Cancer Cell, McBride and colleagues report that the synovial sarcoma SS18-SSX fusion drives BAF complex recruitment to bivalent domains repressed by PRC2 complex to orchestrate aberrant transcriptional activation. Redistribution of BAF localization is a major driver of synovial sarcoma proliferation and presents a promising therapeutic target. In this issue of Cancer Cell, McBride and colleagues report that the synovial sarcoma SS18-SSX fusion drives BAF complex recruitment to bivalent domains repressed by PRC2 complex to orchestrate aberrant transcriptional activation. Redistribution of BAF localization is a major driver of synovial sarcoma proliferation and presents a promising therapeutic target.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1
ISSN:	1535-6108 1878-3686
DOI:	10.1016/j.ccell.2018.05.011