New Developments in the Staging of Melanoma

As the incidence of melanoma increases, so does the search for new staging techniques that may provide important prognostic information and aid in the detection of early metastatic disease. The application of molecular techniques may provide powerful new tools in this search. This review summarizes...

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Bibliographic Details
Published in:	Cancer investigation Vol. 23; no. 6; pp. 561 - 567
Main Authors:	Baruch, Amy C., Shi, Jiaqi, Feng, Yongmei, Nelson, Mark A.
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 2005 Taylor & Francis
Subjects:	Biomarkers, Tumor - analysis cDNA arrays Humans Melanoma Melanoma - genetics Melanoma - pathology Molecular techniques Neoplasm Staging Oligonucleotide Array Sequence Analysis Proteomics Reverse Transcriptase Polymerase Chain Reaction RT-PCR Skin Neoplasms - genetics Skin Neoplasms - pathology Staging
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Summary:	As the incidence of melanoma increases, so does the search for new staging techniques that may provide important prognostic information and aid in the detection of early metastatic disease. The application of molecular techniques may provide powerful new tools in this search. This review summarizes recent findings obtained by means of conventional RT-PCR, cDNA arrays, and proteomics in the investigation of human melanoma. The molecular tools discussed in this review demonstrate how global transcript and protein analysis might contribute not only to the staging of melanoma, but may hold great promise in improving the diagnosis and treatment of this disease.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0735-7907 1532-4192
DOI:	10.1080/07357900500202887