KDM4B: A promising oncology therapeutic target

• Published in: Cancer science Vol. 115; no. 1; pp. 8 - 16
• Main Authors: Ni, Fangjing, Tang, Heting, Cheng, Siteng, Yu, Yaoyu, Yuan, Zhihao, Chen, Yingfei, Zhang, Encheng, Wang, Xiang
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01-01-2024; John Wiley and Sons Inc
• Subjects: Apoptosis; Binding sites; cancer therapeutic targets; Cell cycle; Demethylation; DNA biosynthesis; DNA damage; DNA methylation; DNA repair; Efficiency; Enzymes; Epigenetics; Gene expression; histone demethylase; Histones; Hypoxia; KDM4B; Oncology; Physiology; Proteins; Review; Stem cells; Structure-function relationships; Therapeutic targets; Tumorigenesis; cancer therapeutic targets; KDM4B; histone demethylase; review; oncology
• ISSN: 1347-9032; 1349-7006; 1349-7006
• DOI: 10.1111/cas.16005

Epigenetic modifications are significant in tumor pathogenesis, wherein the process of histone demethylation is indispensable for regulating gene transcription, apoptosis, DNA replication, and repair of damaged DNA. The lysine demethylases (KDMs) serve an essential role in the aforementioned processes, with particular emphasis on the KDM4 family, also referred to as JMJD2. Multiple studies have underscored the significance of the KDM4 family in the regulation of various biological processes including, but not limited to, the cell cycle, DNA repair mechanisms, signaling pathways, and the progression of tumor formation. Nevertheless, it is imperative to elucidate the underlying mechanism of KDM4B, which belongs to the KDM4 gene family. This review presents a comprehensive examination of the structure, mechanism, and function of KDM4B, as well as a critical analysis of the current body of research pertaining to its involvement in tumorigenesis and development. Furthermore, this review explores the potential therapeutic strategies that specifically target KDM4B.
This review presents a comprehensive examination of the structure, mechanism, and function of KDM4B, as well as a critical analysis of the current body of research pertaining to its involvement in tumorigenesis and development. Furthermore, this review explores the potential therapeutic strategies that specifically target KDM4B.