Guanine nucleotide binding‐protein coupled signaling pathway regulation of osteoblast‐mediated bone formation

• Published in: Journal of bone and mineral research Vol. 11; no. 10; pp. 1375 - 1383
• Main Authors: Quarles, L.D., Siddhanti, S.R.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Washington, DC John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 01-10-1996; American Society for Bone and Mineral Research
• Subjects: Binding Sites; Biological and medical sciences; Bone Development - genetics; Bone Development - physiology; Bone Remodeling - genetics; Fundamental and applied biological sciences. Psychology; GTP-Binding Proteins - genetics; GTP-Binding Proteins - metabolism; Humans; Osteoblasts - cytology; Osteoblasts - metabolism; Osteoporosis - etiology; Osteoporosis - genetics; Receptors, Parathyroid Hormone - genetics; Receptors, Parathyroid Hormone - metabolism; Signal Transduction - genetics; Skeleton and joints; Transcription, Genetic - genetics; Vertebrates: osteoarticular system, musculoskeletal system; Osteoarticular system; Binding protein; Parathormone; Signal transduction; Parathyroid hormone; Osteoblast; Bone; Review; Osteogenesis; G protein
• ISSN: 0884-0431; 1523-4681
• DOI: 10.1002/jbmr.5650111002

The challenge for successfully treating established osteoporosis is to develop ways to modulate bone remodeling selectively and/or differentially. There are numerous growth factors and cytokines that affect osteoblast growth and development. Of these, the pharmacologic manipulation of hormone receptor-G-protein signal transduction pathways currently offers the greatest potential to achieve selective control of osteoblast function leading to uncoupled bone formation. This editorial review describes some of the important advances in our understanding of G-protein-coupled receptor signaling specificity in osteoblasts and how the stage of osteoblast development might influence hormone responsiveness.