Versicones E–H and arugosin K produced by the mangrove-derived fungus Aspergillus versicolor HDN11-84

• Published in: Journal of antibiotics Vol. 70; no. 2; pp. 174 - 178
• Main Authors: Li, Feng, Guo, Wenqiang, Che, Qian, Zhu, Tianjiao, Gu, Qianqun, Li, Dehai
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-02-2017; Nature Publishing Group
• Subjects: 639/638/403/936; Antibiotics; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; Aspergillus - classification; Aspergillus - metabolism; Aspergillus versicolor; Bacteriology; Benzopyrans - chemistry; Benzopyrans - metabolism; Benzopyrans - pharmacology; Benzoxepins - chemistry; Benzoxepins - metabolism; Benzoxepins - pharmacology; Biomedical and Life Sciences; Bioorganic Chemistry; Cell culture; Cell Line, Tumor; Chromatography; Cytotoxicity; Data analysis; Fungi; Humans; Laboratories; Life Sciences; Medicinal Chemistry; Microbiology; Molecular Structure; NMR; Nuclear magnetic resonance; Organic Chemistry; original-article; Pharmacy; Toxicity; Xanthones - chemistry; Xanthones - metabolism; Xanthones - pharmacology
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/ja.2016.95

Four new xanthonoids, versicones E–H (
1–4
), and a biogenetically related new derivative arugosin K (
5
), were isolated from a culture extract of the mangrove-derived fungus
Aspergillus versicolor
HDN11-84. Their structures were elucidated on the basis of extensive NMR spectroscopic data analysis. Versicone E (
1
) represents the first example of naturally occurring xanthonoids containing a 2-butenamide moiety. Among them,
5
showed the best cytotoxicity against Hela cell line with an IC
50
value of 9.2 μ
m
.