Primary clear cell adenocarcinoma of the vagina not associated with diethylstilbestrol: A case report

Primary vaginal cancers are rare and clear cell adenocarcinoma is a malignant tumor that is all the more rare when the woman has not been exposed in utero to synthetic diethylstilboestrol (DES). We report the case of a 60-year-old woman with a history of balanced essential hypertension and partial m...

Full description

Saved in:
Bibliographic Details
Published in:International journal of surgery case reports Vol. 98; p. 107460
Main Authors: Haddout, S., Imami, Y., Benhessou, M., Ennachit, M., El Karroumi, M.
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-09-2022
Elsevier
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Primary vaginal cancers are rare and clear cell adenocarcinoma is a malignant tumor that is all the more rare when the woman has not been exposed in utero to synthetic diethylstilboestrol (DES). We report the case of a 60-year-old woman with a history of balanced essential hypertension and partial mastectomy for neoplasia, who presented with a recurrent left inguinal adenopathy. Clinical examination revealed a 3 cm bulging lesion of the anterior vaginal wall in the lower third with indurated left inguinal adenopathy. Biopsy of the nodule showed an invasive clear cell adenocarcinoma. The extension bialn is negative and the multidisciplinary decision is to perform a partial colpectomy with bilateral inguinal curage. The patient is currently undergoing radiochemotherapy. This is a rare case with a poor prognosis. A poor response to adjuvant therapy with a high frequency of distant metastases is reported in the literature. Due to the rarity of this pathology, individual experience based on case reports is the main source of information. The most effective mode of treatment therefore remains unknown and depends on patient-specific factors such as tumor size, surgeon and oncologist team experiences. •Clear cell adenocarcinoma are all the more rare when the woman has not been exposed in utero to DES.•Clinical examination is important for diagnosis, treatment and prognosis.•MRI is the most reliable imaging technique to assess the stage of the tumor,•Depending on the grade of the disease, most patients are treated with a combination of radical surgery and radiotherapy•The most effective mode of treatment depends on tumor size, surgeon and oncologist team experiences.
Bibliography:Professor.
Intern.
Head of department.
ISSN:2210-2612
2210-2612
DOI:10.1016/j.ijscr.2022.107460